Neurons trapped in deep cerebellar nets: what deactivating the surface can do to the depths
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Title
Neurons trapped in deep cerebellar nets: what deactivating the surface can do to the depthsAuthor (s)
Tutor/Supervisor; University.Department
Miquel, Marta; Gil Miravet, Isis; Universitat Jaume I. Departament de Psicologia Bàsica, Clínica i PsicobiologiaDate
2018-09-10Publisher
Universitat Jaume IAbstract
Despite recent evidences linking the cerebellum to relevant brain functions affected in addicts
it is still being ignored in addiction research. Several studies unveiled its involvement in the
development of pavlovian ... [+]
Despite recent evidences linking the cerebellum to relevant brain functions affected in addicts
it is still being ignored in addiction research. Several studies unveiled its involvement in the
development of pavlovian learning, acquisition and consolidation of emotional and cueinduced drug memories. Perineuronal nets (PNNs) are lattice-like structures made out of
extracellular matrix components wrapped around special subsets of neurons. PNNs play a
major role in stabilizing neuronal connections by reducing structural plasticity. It is known that
this might be the underlying structural mechanism behind long-term memory storage;
therefore PNNs would be significantly involved in the acquisition and expression of druginduced memories. In the present study we trained rats in cocaine-induced odor preference
conditioning in order to acquire cue-induced drug-memories. Also, animals were lesioned with
quinolinic acid in posterior cerebellum. We assessed neural activity and plasticity changes in
deep cerebellar nuclei through cFos and PNN expression. Our results showed that the majority
of neurons expressing strong PNNs in posterior interpositum displayed increased cFos activity. [-]
Subject
Description
Treball Final de Màster Universitari en Investigació en Cervell i Conducta. Codi: SBM024. Curs: 2017/2018
Type
info:eu-repo/semantics/masterThesisRights
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