Caffeine Modulates Food Intake Depending on the Context That Gives Access to Food: Comparison With Dopamine Depletion
View/ Open
Impact
Scholar |
Other documents of the author: Correa, Merce; San Miguel Segura, Noemí; López Cruz, Laura; Carratalá-Ros, Carla; Olivares-García, Régulo; Salamone, John
Metadata
Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
comunitat-uji-handle4:
INVESTIGACIONMetadata
Title
Caffeine Modulates Food Intake Depending on the Context That Gives Access to Food: Comparison With Dopamine DepletionAuthor (s)
Date
2018-09-06Bibliographic citation
CORREA SANZ, Mercé; SAN MIGUEL SEGURA, Noemí; LÓPEZ CRUZ, Laura; CARRATALÁ ROS, Carla; OLIVARES GARCÍA, Régulo Luis; SALAMONE, John D. (2018). Caffeine Modulates Food Intake Depending on the Context That Gives Access to Food: Comparison With Dopamine Depletion. Frontiers in Psychiatry, v. 9,Type
info:eu-repo/semantics/articlePublisher version
https://www.frontiersin.org/articles/10.3389/fpsyt.2018.00411/fullVersion
info:eu-repo/semantics/publishedVersionSubject
Abstract
Caffeine is a methylxanthine consumed in different context
s to potentiate alertness and
reduce fatigue. However, caffeine can induce anxiety at hig
h doses. Caffeine is also
a minor psychostimulant that seems to ... [+]
Caffeine is a methylxanthine consumed in different context
s to potentiate alertness and
reduce fatigue. However, caffeine can induce anxiety at hig
h doses. Caffeine is also
a minor psychostimulant that seems to act as an appetite supp
ressant, but there are
also reports indicating that it could stimulate appetite. D
opamine also is involved in food
motivation and in behavioral activation. In the present ser
ies of experiments, we evaluated
the effects of acute administration of caffeine on food cons
umption under different access
conditions. CD1 male adult mice had access to highly palatab
le food (50% sucrose)
in a restricted but habitual context, under continuous or in
termittent access as well as
under anxiogenic, or effortful conditions. Caffeine (2.5–
20.0 mg/kg) increased intake at
the highest dose under familiar continuous and intermitten
t access. However, this high
dose reduced food intake in the dark-light paradigm. In cont
rast, a dopamine-depleting
agent, tetrabenazine (TBZ; 1.0–8.0 mg/kg) did not affect fo
od intake in any of those
experimental conditions. In the T-maze-barrier task that e
valuates seeking and taking
of food under effortful conditions, caffeine (10.0 mg/kg) d
ecreased latency to reach the
food, but did not affect selection of the high-food density a
rm that required more effort,
or the total amount of food consumed. In contrast, TBZ (4.0 mg
/kg) reduced selection
of the high food density arm with the barrier, thus affecting
amount of food consumed.
Interestingly, a small dose of caffeine (5.0 mg/kg) was able
to reverse the anergia-inducing
effects produced by TBZ in the T-maze. These results suggest
that caffeine can potentiate
or suppress food consumption depending on the context. More
over, caffeine did not
change appetite, and did not impair orientation toward food
under effortful conditions,
but it rather helped to achieve the goal by improving speed an
d by reversing performance
to normal levels when fatigue was induced by dopamine deplet
ion. [-]
Is part of
Frontiers in Psychiatry (2018), v. 9Rights
info:eu-repo/semantics/openAccess
This item appears in the folowing collection(s)
- PSB_Articles [1315]
The following license files are associated with this item: