Synthesis of small peptides for biomedical applications
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comunitat-uji-handle2:10234/71324
comunitat-uji-handle3:10234/98504
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Título
Synthesis of small peptides for biomedical applicationsAutoría
Tutor/Supervisor; Universidad.Departamento
Escuder, Beatriu; Universitat Jaume I. Departament de Química Inorgànica i OrgànicaFecha de publicación
2018-06Editor
Universitat Jaume IResumen
The objective of this study is the design of small peptides for biomedical applications,
constructing biocompatible hydrogels able to respond to an external stimulus and
form gel in a different pH. Mai ... [+]
The objective of this study is the design of small peptides for biomedical applications,
constructing biocompatible hydrogels able to respond to an external stimulus and
form gel in a different pH. Mainly, we focus on the creation of a small peptide that
forms a gel able to release the drug in response to a pH change similar to that found
between the external and internal skin that could be useful for the treatment of skin
wounds.
As we know because of the previous studies done in the Dr. Beatriu Escuder research
group, these three dipeptides are good gelators.
We will try to synthesize these three dipeptides and then characterize them.
The only commercial product from them is ZFFOH, so we decide to use it like model
compound to determine the final methodology to assembly the hydrazine that allow
us to form bonds with drugs that contain carboxyl group, like ketone and aldehyde
group.
Once characterized, we will proceed to the assembly of the hydrazide with the ketone
and aldehyde groups. We will have to check once purified that they can form gels, and
do drug release tests. This could make possible the controlled release of drugs, for
example in skin wounds to help the healing of it, which would be a long term objective. [-]
Palabras clave / Materias
Descripción
Treball Final de Grau en Química. Codi: QU0943. Curs acadèmic: 2017/2018
Tipo de documento
info:eu-repo/semantics/bachelorThesisDerechos de acceso
info:eu-repo/semantics/openAccess
Aparece en las colecciones
- Grau en Química [265]
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