What about the herb? A new metabolomics approach for synthetic cannabinoid drug testing
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Altres documents de l'autoria: Bijlsma, Lubertus; Gil Solsona, Ruben; Hernandez, Felix; Sancho, Juan V
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What about the herb? A new metabolomics approach for synthetic cannabinoid drug testingData de publicació
2018-08Editor
Springer VerlagISSN
1618-2642; 1618-2650Cita bibliogràfica
BIJLSMA, Lubertus, et al. What about the herb? A new metabolomics approach for synthetic cannabinoid drug testing. Analytical and bioanalytical chemistry, 2018, vol. 410, no 21, p. 5107–5112.Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
https://link.springer.com/article/10.1007/s00216-018-1182-8Versió
info:eu-repo/semantics/submittedVersionParaules clau / Matèries
Resum
Synthetic cannabinoids (SCs) are consumed as legal alternative to cannabis and often allow passing drug-screening tests. Their rapid transience on the drug scene, combined with their mostly unknown metabolic profiles, ... [+]
Synthetic cannabinoids (SCs) are consumed as legal alternative to cannabis and often allow passing drug-screening tests. Their rapid transience on the drug scene, combined with their mostly unknown metabolic profiles, creates a scenario with constantly moving analytical targets, making their monitoring and identification challenging. The development of fast screening strategies for SCs, not directly focused on their chemical structure, as an alternative to the commonly applied target acquisition methods, would be highly appreciated in forensic and public health laboratories. An innovative untargeted metabolomics approach, focused on herbal components commonly used for ‘spice’ products, was applied. Saliva samples of healthy volunteers were collected at pre-dose and after smoking herbal components and analysed by high-resolution mass spectrometry. The data obtained, combined with appropriate statistical analysis, allowed to highlight and elucidate two markers (scopoletin and N,N-bis(2-hydroxyethyl)dodecylamine), which ratio permitted to differentiate herbal smokers from non-smokers. The proposed strategy will allow discriminating potential positives, on the basis of the analysis of two markers identified in the herbal blends. This work is presented as a step forward in SC drug testing, promoting a smart first-line screening approach, which will allow reducing the number of samples to be further investigated by more sophisticated HRMS methods. [-]
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Analytical and bioanalytical chemistry, 2018, vol. 410, no 21Drets d'accés
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