Spanish consensus on treat to target for osteoporosis
View/ Open
Impact
Scholar |
Other documents of the author: Nogués Solán, Xavier; Nolla, J. M.; Casado, E.; Jódar, E.; Muñoz-Torres, M.; Quesada-Gómez, J. M.; Canals, L.; Balcells, M.; Lizán, Luis
Metadata
Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
comunitat-uji-handle4:
INVESTIGACIONMetadata
Title
Spanish consensus on treat to target for osteoporosisAuthor (s)
Date
2018Publisher
Springer VerlagISSN
0937-941X; 1433-2965Bibliographic citation
Nogués, X., Nolla, J.M., Casado, E. et al. Osteoporos Int (2018) 29: 489. https://doi.org/10.1007/s00198-017-4310-yType
info:eu-repo/semantics/articlePublisher version
https://link.springer.com/article/10.1007/s00198-017-4310-yVersion
info:eu-repo/semantics/publishedVersionSubject
Abstract
Summary
To reach a Spanish expert consensus on a treat-to-target strategy in osteoporosis, a Delphi Consensus Study has been developed. Most of the experts (59.8%) were rheumatologist with a mean clinical experience ... [+]
Summary
To reach a Spanish expert consensus on a treat-to-target strategy in osteoporosis, a Delphi Consensus Study has been developed. Most of the experts (59.8%) were rheumatologist with a mean clinical experience of 21.3 years (SD 8.5). Consensus was achieved for 70% of the items. Therapeutic objectives, patient follow-up scheme, treatment failure criteria, and appropriate treatment choice for use in T2T strategy in Spain have been defined.
Introduction
The paper aims to achieve a Spanish expert consensus on a treat-to-target (T2T) strategy in osteoporosis.
Methods
A scientific committee led the project and was involved in expert panel identification and Delphi questionnaire development. Two Delphi rounds were completed. The first-round questionnaire included 24 items and assessed, using a seven-point Likert scale, the experts’ wish (W) and prognosis (P) in 5 years for each topic (applicability, therapeutic objectives, patient follow-up, and possible treatment to be prescribed). Items for which there was no consensus in the first round were included in the second round. Consensus was defined as ≥75% agreement (somewhat/mostly/entirely agree) or disagreement (somewhat/mostly/entirely disagree) responses.
Results
Of the experts, 112 and 106 completed the first and second rounds, respectively. 59.8% were rheumatologists with a mean clinical experience of 21.3 years (SD 8.5). Consensus was achieved for 70% of the items, and was established regarding the utility of a T2T strategy to define therapeutic objectives, optimal follow-up, and therapeutic algorithm. Participants agreed on the utility of the bone mineral density (BMD) value (T-score >−2.5 SD for spine and >−2.5/−2.0 SD for femoral neck), lack of fractures, and fracture risk (FRAX) as therapeutic objectives. For measuring BMD changes, consensus was achieved on the suitability of hip and femoral neck locations. Experts agreed to consider treatment failure as when a significant BMD gain could not be achieved, or when a new fracture occurs within 2–3 years. There was consensus that all proposed therapies should achieve a therapeutic target through T2T strategy (treatments with the highest consensus scores were denosumab and teriparatide).
Conclusion
The therapeutic objectives, patient follow-up scheme, treatment failure criteria, and appropriate treatment choice for use in T2T strategy in Spain have been established by a panel of experts. Some aspects nevertheless still require further analysis. [-]
Is part of
Osteoporos Int (2018) 29Rights
info:eu-repo/semantics/openAccess
This item appears in the folowing collection(s)
- MED_Articles [641]
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as © The Author(s) 2017
This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.