The renaissance of acetaldehyde as a psychoactive compound: decades in the making
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The renaissance of acetaldehyde as a psychoactive compound: decades in the makingData de publicació
2014-07-22Editor
Frontiers MediaCita bibliogràfica
CORREA SANZ, Mercè; ACQUAS, Elio; SALAMONE, John D. (2014). The renaissance of acetaldehyde as a psychoactive compound: decades in the making. Frontiers in Behavioral Neuroscience, v. 8Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
https://www.frontiersin.org/articles/10.3389/fnbeh.2014.00249/fullVersió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
As with many events in the history of science, the development
of the hypothesis that acetaldehyde is a plausible psychoactive
substance with specific central effects (not related to its toxic-
ity) has not been ... [+]
As with many events in the history of science, the development
of the hypothesis that acetaldehyde is a plausible psychoactive
substance with specific central effects (not related to its toxic-
ity) has not been either incremental or progressive. Rather, it has
evolved through a process of fits and starts. Initial clinical obser-
vations suggesting that accumulation of acetaldehyde could be
used as a therapy for alcoholism did not lead to a highly effective
treatment, and in fact, it was noted early on that small amounts
of ethanol consumed under these conditions (i.e., blockade of
aldehyde dehydrogenase) could be perceived as being even more
pleasurable (
Chevens, 1953
). Although some laboratory data in
animals appeared at that time (
Carpenter and Macleod, 1952), it
took a decade for the pre-clinical studies to focus on the poten-
tial importance of acetaldehyde. Since Myers proposed in the late
60’s that acetaldehyde could be a mediator of some of the effects
of ethanol (
Myers and Veale, 1969), advances in this field have
gone through a push-pull process. [-]
Publicat a
Frontiers in Behavioral Neuroscience (2014), v. 8Proyecto de investigación
Support from 1) Plan Nacional de Drogas (2010I024), Spain; 2) NIH/NIMH (MH078023-01A1), USA; 3) Italian Ministry of University and Research (MIUR, PRIN 2006), and 4) The Regione Autonoma della Sardegna (RAS), Italy, Regional Law n°7/2007, n°F71J090006200002 and B71J11001480002_1.Drets d'accés
info:eu-repo/semantics/openAccess
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