Enhancement of plasma protein adsorption and osteogenesis of hMSCs by functionalized siloxane coatings for titanium implants
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Other documents of the author: Ibáñez, Maria; Sanjeeva Murthy, N.; Mao, Yong; Suay, Julio; GURRUCHAGA, MARILO; Goñi, Isabel; Kohn, Joachim
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comunitat-uji-handle2:10234/7034
comunitat-uji-handle3:10234/8619
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Title
Enhancement of plasma protein adsorption and osteogenesis of hMSCs by functionalized siloxane coatings for titanium implantsAuthor (s)
Date
2018-03Publisher
WileyType
info:eu-repo/semantics/articlePublisher version
https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.b.33889Version
info:eu-repo/semantics/draftSubject
Abstract
A series of sol–gel derived silicon based coatings
were developed to improve the osseointegration of commer-
cial titanium dental implants. The osseointegration starts
with a positive interaction between the implant ... [+]
A series of sol–gel derived silicon based coatings
were developed to improve the osseointegration of commer-
cial titanium dental implants. The osseointegration starts
with a positive interaction between the implant surface and
surrounding tissues, which is facilitated by the adsorption of
plasma proteins onto the biomaterial surface immediately
after implantation. It is likely that the enhancement of protein
adsorption to titanium implants leads to a better implant/tis-
sue integration. In addition, silica based biomaterials have
been shown to promote osteoblast differentiation. To
improve the protein adsorption and the osteogenesis, meth-
yltrimethoxysilane (MTMOS), tetraethoxysilane (TEOS), 3-
glycidoxypropyltrimethoxysilane (GPTMS), and gelatin were
selected to coat titanium surfaces. Compared with non-
coated titanium, the functionalized coatings enhanced the adsorption of adhesive proteins such as fibronectin and colla-
gen. The Si release was successfully modulated by the con-
trol of the chemical composition of the coating, showing a
higher dissolution rate with the gelatin and GPTMS incorpo-
ration. While the roughness of commercial implants seemed
to promote the adhesion of mesenchymal stem cells (MSC),
the osteogenic differentiation was greater on surfaces with
Si-coatings. In this study, an improved osteogenic surface
has been achieved by using the siloxane-gelatin coatings and
such coatings can be used in dental implants to promote
osseointegration. [-]
Investigation project
Ministerio de Economía y Competitividad, Govern of Spain (MAT2014‐51918‐C2‐2 R ) ; University of the Basque Country (UFI 11/56; IT 611–13)Rights
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