Accurate cut-offs for predicting endoscopic activity and mucosal healing in Crohn’s disease with fecal calprotectin
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Accurate cut-offs for predicting endoscopic activity and mucosal healing in Crohn’s disease with fecal calprotectinAutoria
Data de publicació
2017Editor
ARAN edicionesCita bibliogràfica
VÁZQUEZ-MORÓN, Juan María, et al. Accurate cut-offs for predicting endoscopic activity and mucosal healing in Crohn's disease with fecal calprotectin. Revista Española de Enfermedades Digestivas, 2017, vol. 109, núm. 2, p.130-136Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
https://www.reed.es/ArticuloFicha.aspx?id=1432&hst=0&idR=45&tp=1&AspxAutoDetectC ...Versió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
Background: Fecal biomarkers, especially fecal calprotectin,
are useful for predicting endoscopic activity in Crohn’s disease;
however, the cut-off point remains unclear. The aim of this paper
was to analyze whether ... [+]
Background: Fecal biomarkers, especially fecal calprotectin,
are useful for predicting endoscopic activity in Crohn’s disease;
however, the cut-off point remains unclear. The aim of this paper
was to analyze whether faecal calprotectin and M2 pyruvate
kinase are good tools for generating highly accurate scores for the
prediction of the state of endoscopic activity and mucosal healing.
Methods: The simple endoscopic score for Crohn’s disease
and the Crohn’s disease activity index was calculated for 71
patients diagnosed with Crohn’s. Fecal calprotectin and M2-PK
were measured by the enzyme-linked immunosorbent assay test.
Results: A fecal calprotectin cut-off concentration of ≥ 170
μg/g (sensitivity 77.6%, specificity 95.5% and likelihood ratio
+17.06) predicts a high probability of endoscopic activity, and a
fecal calprotectin cut-off of ≤ 71 μg/g (sensitivity 95.9%, specificity
52.3% and likelihood ratio -0.08) predicts a high probability of
mucosal healing. Three clinical groups were identified according to
the data obtained: endoscopic activity (calprotectin ≥ 170), mucosal
healing (calprotectin ≤ 71) and uncertainty (71 > calprotectin <
170), with significant differences in endoscopic values (F = 26.407,
p < 0.01). Clinical activity or remission modified the probabilities of
presenting endoscopic activity (100% vs 89%) or mucosal healing
(75% vs 87%) in the diagnostic scores generated. M2-PK was
insufficiently accurate to determine scores.
Conclusions: The highly accurate scores for fecal calprotectin
provide a useful tool for interpreting the probabilities of presenting
endoscopic activity or mucosal healing, and are valuable in the
specific clinical context. [-]
Publicat a
Revista Española de Enfermedades Digestivas, 2017, vol. 109, núm. 2, p.130-136Drets d'accés
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