Efficient and Selective N‐Methylation of Nitroarenes under Mild Reaction Conditions
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7013
comunitat-uji-handle3:10234/8638
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INVESTIGACIONMetadata
Title
Efficient and Selective N‐Methylation of Nitroarenes under Mild Reaction ConditionsAuthor (s)
Date
2017Publisher
WileyISSN
0947-6539; 1521-3765Bibliographic citation
PEDRAJAS, Elena, et al. Efficient and Selective N‐Methylation of Nitroarenes under Mild Reaction Conditions. Chemistry–A European Journal, 2017, vol. 23, no 53, p. 13205-13212.Type
info:eu-repo/semantics/articlePublisher version
https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201702783Version
info:eu-repo/semantics/acceptedVersionSubject
Abstract
Herein, we report a straightforward protocol for the preparation of N,N‐dimethylated amines from readily available nitro starting materials using formic acid as a renewable C1 source and silanes as reducing agents. ... [+]
Herein, we report a straightforward protocol for the preparation of N,N‐dimethylated amines from readily available nitro starting materials using formic acid as a renewable C1 source and silanes as reducing agents. This tandem process is efficiently accomplished in the presence of a cubane‐type Mo3PtS4 catalyst. For the preparation of the novel [Mo3Pt(PPh3)S4Cl3(dmen)3]+ (3+) (dmen: N,N′‐dimethylethylenediamine) compound we have followed a [3+1] building block strategy starting from the trinuclear [Mo3S4Cl3(dmen)3]+ (1+) and Pt(PPh3)4 (2) complexes. The heterobimetallic 3+ cation preserves the main structural features of its 1+ cluster precursor. Interestingly, this catalytic protocol operates at room temperature with high chemoselectivity when the 3+ catalyst co‐exists with its trinuclear 1+ precursor. N‐heterocyclic arenes, double bonds, ketones, cyanides and ester functional groups are well retained after N‐methylation of the corresponding functionalized nitroarenes. In addition, benzylic‐type as well as aliphatic nitro compounds can also be methylated following this protocol. [-]
Is part of
Chemistry–A European Journal, 2017, vol. 23, no 53Investigation project
Spanish Ministerio de Economía y Competitividad: Grant CTQ2015‐65207‐P), Generalitat Valenciana: PrometeoII/2014/022) , Universitat Jaume I: UJI‐A2016‐05Rights
Copyright © John Wiley & Sons, Inc.
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info:eu-repo/semantics/openAccess
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info:eu-repo/semantics/openAccess
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