Study of drugs of abuse consumption by wastewater analysis using UHPLC-MS/MS (QqQ). An attempt to update the methodology
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Study of drugs of abuse consumption by wastewater analysis using UHPLC-MS/MS (QqQ). An attempt to update the methodologyAutoria
Tutor/Supervisor; Universitat.Departament
Pitarch Arquimbau, María Elena; Universitat Jaume I. Departament de Química Física i AnalíticaData de publicació
2017Editor
Universitat Jaume IResum
Nowadays, drug use is a reality that we must study to prevent it from getting
popularized and gaining addicts. However, it is a controversial topic and it is
difficult to conduct ... [+]
Nowadays, drug use is a reality that we must study to prevent it from getting
popularized and gaining addicts. However, it is a controversial topic and it is
difficult to conduct non-biased surveys. This is why Wastewater Based
Epidemiology, the analysis of wastewater to obtain DOAs consumption data, is an
excellent tool to obtain realistic data without consulting the population. The use
of this methodology is becoming more and more popular.
The research was carried out for a city on the Mediterranean coast for two weeks,
a normal week and a festive week in order to compare drug consumption. The
substances studied were: MDMA, Methamphetamine, Cocaine, Benzoylecgonine,
THC-COOH, Morphine, 6-MAM, Heroin and Ketamine. In addition, a comparison
study was carried out between different SPE cartridges to improve the current
methodology.
For accomplishing both objectives, ultra-high performance liquid chromatography
coupled to triple quadrupole with electrospray ionization (UHPLC-MS/MS (QqQ)
was used.
Higher drug intakes were found during weekends and festivities for stimulant
drugs such as cocaine and MDMA. In addition, it was verified that drugs like
cannabis and morphine, which are known to have relaxing effects, have a more
constant consumption not only in a normal week but in a festive week.
Additionally, it was proved that the use of new-generation SPE cartridges did not
sustainably improve the previously used methodology [-]
Paraules clau / Matèries
Descripció
Treball Final de Grau en Química. Codi: QU0943. Curs acadèmic: 2016/2017.
Tipus de document
info:eu-repo/semantics/bachelorThesisDrets d'accés
info:eu-repo/semantics/openAccess
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- Grau en Química [265]