Tuneable 3D printed bioreactors for transaminations under continuous-flow
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http://dx.doi.org/10.1039/c7gc02421e |
Metadata
Title
Tuneable 3D printed bioreactors for transaminations under continuous-flowAuthor (s)
Date
2017-11-21Publisher
Royal Society of ChemistryBibliographic citation
PERIS, Edgar; OKAFOR, Obinna; KULCINSKAJA, Evelina; GOODRIDGE, Ruth; LUIS LAFUENTE, Santiago Vicente; GARCÍA VERDUGO, Eduardo; O'REILLY, Elaine; SANS, Víctor. Tuneable 3D printed bioreactors for transaminations under continuous-flow. Green Chemistry (2017), v. 19, n. 21, p. 5345-5349Type
info:eu-repo/semantics/articlePublisher version
http://pubs.rsc.org/en/content/articlepdf/2017/gc/c7gc02421eVersion
info:eu-repo/semantics/publishedVersionSubject
Abstract
A method to efficiently immobilize enzymes on 3D printed continuous-
fl
ow devices is presented. Application of these chemically
modi
fi
ed devices enables rapid screening of immobilization
mechanisms and ... [+]
A method to efficiently immobilize enzymes on 3D printed continuous-
fl
ow devices is presented. Application of these chemically
modi
fi
ed devices enables rapid screening of immobilization
mechanisms and reaction conditions, simple transfer of optimised
conditions into tailored printed micro
fl
uidic reactors and development of continuous-
fl
ow biocatalytic processes. The bioreactors
showed good activity (8
–
20.5
μ
mol h
−
1
mg
enz
−
1
) in the kinetic
resolution of 1-methylbenzylamine, and very good stability (
ca.
100 h under
fl
ow). [-]
Is part of
Green Chemistry (2017), issue 19, n. 22Investigation project
1) The Royal Society (RG150021) for funding ; 2) The Research Priority Area (RPA) of UoN in Industrial Biotechnology for funding; 3) Funding from the BBSRC (BB/M021947/1); 4) EPSRC (EP/I033335/2); 5) Partially supported by G. V. (PROMETEO 2016-071) and 6) MINECO (CTQ2015-68429R); 7) MICINN for personal financial support (FPU13/00685))Rights
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/restrictedAccess
info:eu-repo/semantics/restrictedAccess
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