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Oral Ingestion and Intraventricular Injection of Curcumin Attenuates the Effort-Related Effects of the VMAT-2 Inhibitor Tetrabenazine: Implications for Motivational Symptoms of Depression
dc.contributor.author | Yohn, Samantha E. | |
dc.contributor.author | Gorka, Dea | |
dc.contributor.author | Mistry, Anisha | |
dc.contributor.author | Collins, Samantha | |
dc.contributor.author | Qian, Emily | |
dc.contributor.author | Correa, Merce | |
dc.contributor.author | Manchanda, Arushi | |
dc.contributor.author | Bogner, Robin | |
dc.contributor.author | Salamone, John | |
dc.date.accessioned | 2018-03-07T12:42:12Z | |
dc.date.available | 2018-03-07T12:42:12Z | |
dc.date.issued | 2017-09 | |
dc.identifier.citation | YOHN, Samantha E., et al. Oral Ingestion and Intraventricular Injection of Curcumin Attenuates the Effort-Related Effects of the VMAT-2 Inhibitor Tetrabenazine: Implications for Motivational Symptoms of Depression. Journal of natural products, 2017, vol. 80, no 10, p. 2839-2844. | ca_CA |
dc.identifier.uri | http://hdl.handle.net/10234/173227 | |
dc.description.abstract | Effort-related choice tasks are used for studying depressive motivational symptoms such as anergia/fatigue. These studies investigated the ability of the dietary supplement curcumin to reverse the low-effort bias induced by the monoamine storage blocker tetrabenazine. Tetrabenazine shifted effort-related choice in rats, decreasing high-effort lever pressing but increasing chow intake. The effects of tetrabenazine were reversed by oral ingestion of curcumin (80.0–160.0 mg/kg) and infusions of curcumin into the cerebral ventricles (2.0–8.0 μg). Curcumin attenuates the effort-related effects of tetrabenazine in this model via actions on the brain, suggesting that curcumin may be useful for treating human motivational symptoms. | ca_CA |
dc.format.extent | 5 p. | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | American Chemical Society | ca_CA |
dc.rights | Copyright © 2017 The American Chemical Society and American Society of Pharmacognosy | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | curcumin | ca_CA |
dc.subject | depression | ca_CA |
dc.subject | tetrabenazine | ca_CA |
dc.title | Oral Ingestion and Intraventricular Injection of Curcumin Attenuates the Effort-Related Effects of the VMAT-2 Inhibitor Tetrabenazine: Implications for Motivational Symptoms of Depression | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.1021/acs.jnatprod.7b00425 | |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
dc.relation.publisherVersion | https://pubs.acs.org/doi/abs/10.1021/acs.jnatprod.7b00425 | ca_CA |
dc.contributor.funder | Connecticut Diet and Health Initiative; University of Connecticut, Department of Psychological Sciences; University of Connecticut Research Foundation | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
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