Unique Organization of the Nuclear Envelope in the Post-natal Quiescent Neural Stem Cells

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Title
Unique Organization of the Nuclear Envelope in the Post-natal Quiescent Neural Stem Cells
Author (s)
 Cebrián-Silla, Arantxa;
 Alfaro-Cervelló, Clara;
 Herranz-Pérez, Vicente;
 Kaneko, Naoko;
 Park, Dae Hwi;
 Sawamoto, Kazunobu;
 Alvarez-Buylla, Arturo;
 Lim, Daniel A.;
 García-Verdugo, Jose Manuel
Date
2017
Publisher
Elsevier (Cell Press)
URI
http://hdl.handle.net/10234/171294
DOI
http://dx.doi.org/10.1016/j.stemcr.2017.05.024
ISSN
2213-6711
Bibliographic citation
Cebrián-Silla, A., Alfaro-Cervelló, C., Herranz-Pérez, V., Kaneko, N., Park, D. H., Sawamoto, K., ... & García-Verdugo, J. M. (2017). Unique organization of the nuclear envelope in the post-natal quiescent neural stem cells. Stem Cell Reports, 9(1), 203-216.
Type
info:eu-repo/semantics/article
Publisher version
http://www.cell.com/stem-cell-reports/fulltext/S2213-6711(17)30231-X
Version
info:eu-repo/semantics/publishedVersion
Abstract
Neural stem cells (B1 astrocytes; NSCs) in the adult ventricular-subventricular-zone (V-SVZ) originate in the embryo. Surprisingly, recent work has shown that B1 cells remain largely quiescent. They are reactivated ... [+]
Neural stem cells (B1 astrocytes; NSCs) in the adult ventricular-subventricular-zone (V-SVZ) originate in the embryo. Surprisingly, recent work has shown that B1 cells remain largely quiescent. They are reactivated postnatally to function as primary progenitors for neurons destined for the olfactory bulb and some corpus callosum oligodendrocytes. The cellular and molecular properties of quiescent B1 cells remain unknown. Here we found that a subpopulation of B1 cells has a unique nuclear envelope invagination specialization similar to envelope-limited chromatin sheets (ELCS), reported in certain lymphocytes and some cancer cells. Using molecular markers, [3H]thymidine birth-dating, and Ara-C, we found that B1 cells with ELCS correspond to quiescent NSCs. ELCS begin forming in embryonic radial glia cells and represent a specific nuclear compartment containing particular epigenetic modifications and telomeres. These results reveal a unique nuclear compartment in quiescent NSCs, which is useful for identifying these primary progenitors and study their gene regulation. [-]
Is part of
Stem Cell Reports, 2017, vol. 9, núm. 1, p. 203-216
Investigation project
This research was supported by the Prometeo grant PROMETEOII/2014/075 and the MINECO/FEDER grant ( BFU2015-64207-P ). A.C.-S. was supported by the MINECO scholarship (FPU, AP-2010-4264 ). JSPS Program for Advancing Strategic International Networks to Accelerate the Circulation of Talented Researchers (Nagoya City University).
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info:eu-repo/semantics/openAccess
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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). © 2017 The Author(s)
Except where otherwise noted, this item's license is described as This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). © 2017 The Author(s)