Naloxone effects on extinction of ethanol- and cocaine-induced conditioned place preference in mice
Impact
Scholar |
Other documents of the author: Font Hurtado, Laura; Houck, Christa A.; Cunningham, Christopher L.
Metadata
Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
comunitat-uji-handle4:
INVESTIGACIONThis resource is restricted
http://doi.org/10.1007/s00213-017-4672-z |
Metadata
Title
Naloxone effects on extinction of ethanol- and cocaine-induced conditioned place preference in miceDate
2017Publisher
Springer VerlagISSN
0033-3158; 1432-2072Bibliographic citation
Font, L., Houck, C.A. & Cunningham, C.L. Psychopharmacology (2017) 234: 2747. https://doi.org/10.1007/s00213-017-4672-zType
info:eu-repo/semantics/articlePublisher version
https://link.springer.com/article/10.1007/s00213-017-4672-z#citeasVersion
info:eu-repo/semantics/publishedVersionSubject
Abstract
Rationale
Previous studies found that naloxone (NLX) facilitated choice extinction of ethanol conditioned place preference (CPP) using long (60 min) test sessions, but there is little information on the variables ... [+]
Rationale
Previous studies found that naloxone (NLX) facilitated choice extinction of ethanol conditioned place preference (CPP) using long (60 min) test sessions, but there is little information on the variables determining this effect.
Objectives
These studies examined repeated exposure to NLX during extinction of ethanol- or cocaine-induced CPP using both short and long tests.
Methods
DBA/2J mice were injected with NLX (0 or 10 mg/kg) before three 10- or 60-min choice extinction tests (experiment 1). All mice received a final 60-min test without NLX. Post-test NLX was given in experiment 2. Experiment 3 tested whether NLX would affect a forced extinction procedure. Experiment 4 tested its effect on extinction of cocaine-induced CPP.
Results
Pre-test (but not post-test) injections of NLX-facilitated choice extinction of ethanol CPP at both test durations. Pre-test NLX also facilitated forced extinction. However, pre-test NLX had no effect on choice extinction of cocaine CPP.
Conclusions
Extinction test duration is not critical for engaging the opioid system during ethanol CPP extinction (experiment 1). Moreover, NLX’s effect does not depend on CPP expression during extinction, just exposure to previously conditioned cues (experiment 3). The null effect of post-test NLX eliminates a memory consolidation interpretation (experiment 2) and the failure to alter cocaine CPP extinction argues against alteration of general learning or memory processes (experiment 4). Overall, these data suggest that the endogenous opioid system mediates a conditioned motivational effect that normally maintains alcohol-induced seeking behavior, which may underlie the efficacy of opiate antagonists in the treatment of alcoholism. [-]
Is part of
Psychopharmacology (2017) 234Investigation project
R01AA007702Rights
(c) Springer-Verlag GmbH Germany 2017
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/restrictedAccess
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/restrictedAccess
This item appears in the folowing collection(s)
- PSB_Articles [1294]