Synthesis of honokiol analogues and evaluation of their modulating action on VEGF protein secretion and telomerase-related gene expressions
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7053
comunitat-uji-handle3:10234/8639
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INVESTIGACIONMetadata
Title
Synthesis of honokiol analogues and evaluation of their modulating action on VEGF protein secretion and telomerase-related gene expressionsDate
2017-04Publisher
WileyISSN
1747-0277; 1747-0285Bibliographic citation
SÁNCHEZ‐PERIS, María, et al. Synthesis of honokiol analogues and evaluation of their modulating action on VEGF protein secretion and telomerase‐related gene expressions. Chemical biology & drug design, 2017, vol. 89, no 4, p. 577-584.Type
info:eu-repo/semantics/articlePublisher version
http://onlinelibrary.wiley.com/doi/10.1111/cbdd.12880/fullVersion
info:eu-repo/semantics/acceptedVersionSubject
Abstract
A group of 36 biphenyl derivatives structurally related to honokiol were synthesized by means of Suzuki coupling reactions. Their cytotoxicities were evaluated and compared to that of honokiol. Some of the compounds ... [+]
A group of 36 biphenyl derivatives structurally related to honokiol were synthesized by means of Suzuki coupling reactions. Their cytotoxicities were evaluated and compared to that of honokiol. Some of the compounds were then evaluated for their ability to downregulate the secretion of the VEGF protein and the expression of the VEGF, hTERT, and c-Myc genes; the two latter involved in the activation of telomerase in tumoral cells. Some of the synthetized derivatives showed promising pharmacological features as they exhibited IC50 values in low micromolar range, good therapeutic margins, and a multiple mode of action on tumor cells based on the inhibition of VEGF and, at the same time, of the expression of genes related to the activation of telomerase. [-]
Is part of
Chemical biology & drug design, 2017, vol. 89, no 4, p. 577-584Investigation project
Ministerio de Economia y Competitividad of Spain / CTQ201452949-P; Conselleria d' Empresa, Universitat i Ciencia de la Generalitat Valenciana / PROMETEO/2013/027 and ACOMP/2014/274; University Jaume I / PI-1B2011-37Rights
Copyright © John Wiley & Sons, Inc.
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info:eu-repo/semantics/openAccess
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
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- QUIO_Articles [701]