Cerebellar perineuronal nets in cocaine-induced pavlovian memory: Site matters
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Other documents of the author: Carbó Gas, María; Moreno Rius, Josep; Guarque-Chabrera, Julian; Vázquez Sanromán, Dolores; Gil-Miravet, Isis; Carulli, Daniela; Hoebeek, Freek; De Zeeuw, Chris; Sanchis-Segura, Carla; MIQUEL, MARTA
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comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
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https://doi.org/10.1016/j.neuropharm.2017.07.009 |
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Title
Cerebellar perineuronal nets in cocaine-induced pavlovian memory: Site mattersAuthor (s)
Date
2017-07-14Publisher
ElsevierISSN
0028-3908; 1873-7064Bibliographic citation
Carbo-Gas, M., Moreno-Rius, J., Guarque-Chabrera, J., Vazquez-Sanroman, D., Gil-Miravet, I., Carulli, D., ... & Miquel, M. (2017). Cerebellar perineuronal nets in cocaine-induced pavlovian memory: Site matters. Neuropharmacology, 125, pp. 166-180.Type
info:eu-repo/semantics/articlePublisher version
https://www.sciencedirect.com/science/article/pii/S0028390817303271Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
One of the key mechanisms for the stabilization of synaptic changes near the end of critical periods for
experience-dependent plasticity is the formation of specific lattice extracellular matrix structures called
... [+]
One of the key mechanisms for the stabilization of synaptic changes near the end of critical periods for
experience-dependent plasticity is the formation of specific lattice extracellular matrix structures called
perineuronal nets (PNNs). The formation of drug memories depends on local circuits in the cerebellum,
but it is unclear to what extent it may also relate to changes in their PNN. Here, we investigated changes
in the PNNs of the cerebellum following cocaine-induced preference conditioning. The formation of
cocaine-related preference memories increased expression of PNN-related proteins surrounding Golgi
inhibitory interneurons as well as that of cFos in granule cells at the apex of the cerebellar cortex. In
contrast, the expression of PNNs surrounding projection neurons in the medial deep cerebellar nucleus
(DCN) was reduced in all cocaine-treated groups, independently of whether animals expressed a preference
for cocaine-related cues. Discriminant function analysis confirmed that stronger PNNs in Golgi
neurons and higher cFos levels in granule cells of the apex might be considered as the cerebellar hallmarks
of cocaine-induced preference conditioning. Blocking the output of cerebellar granule cells in
a6Cre-Cacna1a mutant mice prevented re-acquisition, but not acquisition, of cocaine-induced preference
conditioning. Interestingly, this impairment in consolidation was selectively accompanied by a reduction
in the expression of PNN proteins around Golgi cells. Our data suggest that PNNs surrounding Golgi
interneurons play a role in consolidating drug-related memories. [-]
Is part of
Neuropharmacology 125 (2017)Funder Name
Ministerio de Educación Cultura y Deporte | Universitat Jaume I | Ministerio de Economía y Competitividad
Investigation project
FPU12/04059 ; PREDOC2014/11 ; 14I307.01/1 ; PSI2015-68600-PRights
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/restrictedAccess
info:eu-repo/semantics/restrictedAccess
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