Fluctuation-Driven Transport in Biological Nanopores. A 3D Poisson–Nernst–Planck Study
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Otros documentos de la autoría: Aguilella-Arzo, Marcel; Queralt-Martín, María; López, María Lidón; Alcaraz, Antonio
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Título
Fluctuation-Driven Transport in Biological Nanopores. A 3D Poisson–Nernst–Planck StudyFecha de publicación
2017Editor
MDPICita bibliográfica
AGUILELLA ARZO, Marcel; QUERALT-MARTÍN, María; LÓPEZ, María Lidón; ALCARAZ GONZÁLEZ, Antonio. Fluctuation-Driven Transport in Biological Nanopores. A 3D Poisson–Nernst–Planck Study. Entropy (2017), v. 19, n. 6Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://www.mdpi.com/1099-4300/19/3/116Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Living systems display a variety of situations in which non-equilibrium fluctuations
couple to certain protein functions yielding astonishing results. Here we study the bacterial channel
OmpF under conditions similar ... [+]
Living systems display a variety of situations in which non-equilibrium fluctuations
couple to certain protein functions yielding astonishing results. Here we study the bacterial channel
OmpF under conditions similar to those met in vivo, where acidic resistance mechanisms are known
to yield oscillations in the electric potential across the cell membrane. We use a three-dimensional
structure-based theoretical approach to assess the possibility of obtaining fluctuation-driven transport.
Our calculations show that remarkably high voltages would be necessary to observe the actual
transport of ions against their concentration gradient. The reasons behind this are the mild selectivity
of this bacterial pore and the relatively low efficiencies of the oscillating signals characteristic of
membrane cells (random telegraph noise and thermal noise). [-]
Publicado en
Entropy (2017), v. 19, n. 6Proyecto de investigación
1) Ministry of Economy and Competitiveness of Spain (Project No. FIS2013-40473-P and FIS2016-75257-P); 2) Universitat Jaume I (Project No. P1.1B2015-28)Derechos de acceso
info:eu-repo/semantics/openAccess
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