Fluctuation-Driven Transport in Biological Nanopores. A 3D Poisson–Nernst–Planck Study
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Altres documents de l'autoria: Aguilella-Arzo, Marcel; Queralt-Martín, María; López, María Lidón; Alcaraz, Antonio
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Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/2507
comunitat-uji-handle3:10234/6973
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INVESTIGACIONMetadades
Títol
Fluctuation-Driven Transport in Biological Nanopores. A 3D Poisson–Nernst–Planck StudyData de publicació
2017Editor
MDPICita bibliogràfica
AGUILELLA ARZO, Marcel; QUERALT-MARTÍN, María; LÓPEZ, María Lidón; ALCARAZ GONZÁLEZ, Antonio. Fluctuation-Driven Transport in Biological Nanopores. A 3D Poisson–Nernst–Planck Study. Entropy (2017), v. 19, n. 6Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
http://www.mdpi.com/1099-4300/19/3/116Versió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
Living systems display a variety of situations in which non-equilibrium fluctuations
couple to certain protein functions yielding astonishing results. Here we study the bacterial channel
OmpF under conditions similar ... [+]
Living systems display a variety of situations in which non-equilibrium fluctuations
couple to certain protein functions yielding astonishing results. Here we study the bacterial channel
OmpF under conditions similar to those met in vivo, where acidic resistance mechanisms are known
to yield oscillations in the electric potential across the cell membrane. We use a three-dimensional
structure-based theoretical approach to assess the possibility of obtaining fluctuation-driven transport.
Our calculations show that remarkably high voltages would be necessary to observe the actual
transport of ions against their concentration gradient. The reasons behind this are the mild selectivity
of this bacterial pore and the relatively low efficiencies of the oscillating signals characteristic of
membrane cells (random telegraph noise and thermal noise). [-]
Publicat a
Entropy (2017), v. 19, n. 6Proyecto de investigación
1) Ministry of Economy and Competitiveness of Spain (Project No. FIS2013-40473-P and FIS2016-75257-P); 2) Universitat Jaume I (Project No. P1.1B2015-28)Drets d'accés
info:eu-repo/semantics/openAccess
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