Adenosine A2A receptor deletion affects social behaviors and anxiety in mice: Involvement of anterior cingulate cortex and amygdala
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Otros documentos de la autoría: López Cruz, Laura; Carbó Gas, María; Pardo, Marta; Bayarri Iturralde, Pilar; Valverde, Olga; LEDENT, Catherine; Salamone, John; Correa, Merce
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Metadatos
Título
Adenosine A2A receptor deletion affects social behaviors and anxiety in mice: Involvement of anterior cingulate cortex and amygdalaAutoría
Fecha de publicación
2017Editor
ElsevierISSN
0166-4328; 1872-7549Cita bibliográfica
LÓPEZ-CRUZ, Laura, et al. Adenosine A 2A receptor deletion affects social behaviors and anxiety in mice: Involvement of anterior cingulate cortex and amygdala. Behavioural brain research, 2017, vol. 321, p. 8-17.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://www.sciencedirect.com/science/article/pii/S0166432816312797Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Blockade of adenosine A2A receptors can potentiate motivation to work for natural reinforcers such as food. Conspecific interaction is a potent natural reinforcer in social animals that can be manifested as preference ... [+]
Blockade of adenosine A2A receptors can potentiate motivation to work for natural reinforcers such as food. Conspecific interaction is a potent natural reinforcer in social animals that can be manifested as preference for social exploration versus other sources of novel stimulation. Deficiencies in this type of motivated behavior (social withdrawal) have been seen in several pathologies such as autism and depression. However, the role of A2A receptors in motivation for social interaction has not been widely explored. Social interaction paradigms evaluate the natural preference of animals for exploring other conspecifics, and the ability to differentiate between familiar versus novel ones. Anxiety is one of the factors that can induce avoidance of social interaction. In the present study, adenosine A2A knockout (A2AKO) and wild-type (WT) mice were assessed for social and anxiety-related behaviors. c-Fos immunoreactivity was evaluated as a measure of neuronal activation in brain areas involved in different aspects of motivation and emotional processes. Although A2AKO mice showed an anxious profile, they displayed higher levels of sociability and were less sensitive to social novelty. WT mice displayed a typical pattern of social recognition 24 h later, but not A2AKO mice, which explored equally both conspecifics. There were no differences between strains in aggressiveness, perseverance or social odor preferences. c-Fos immunoreactivity in A2AKO mice was higher in anterior cingulate and amygdala compared to WT mice. Thus, A2A receptors appear to be potential targets for the improvement of pathologies related to social function. [-]
Publicado en
Behavioural brain research, 2017, vol. 321Proyecto de investigación
Plan Nacional de Drogas/ 2010/024; FPU Ministerio de Educacion /AP2010-3793; Ministerio de Economia-FEDER/SAF2013-41761-RDerechos de acceso
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