Naltrexone Reverses Ethanol-Induced Rat Hippocampal and Serum Oxidative Damage

Almansa, Inmaculada; Barcia, Jorge M; López-Pedrajas, Rosa; Muriach, Maria; Miranda, María; Romero, Francisco J.

dc.contributor.author	Almansa, Inmaculada
dc.contributor.author	Barcia, Jorge M
dc.contributor.author	López-Pedrajas, Rosa
dc.contributor.author	Muriach, Maria
dc.contributor.author	Miranda, María
dc.contributor.author	Romero, Francisco J.
dc.date.accessioned	2017-07-27T11:20:03Z
dc.date.available	2017-07-27T11:20:03Z
dc.date.issued	2013
dc.identifier.citation	Inmaculada Almansa, Jorge M. Barcia, Rosa López-Pedrajas, María Muriach, María Miranda, and Francisco Javier Romero, “Naltrexone Reverses Ethanol-Induced Rat Hippocampal and Serum Oxidative Damage,” Oxidative Medicine and Cellular Longevity, vol. 2013, Article ID 296898, 5 pages, 2013. doi:10.1155/2013/296898	ca_CA
dc.identifier.issn	1942-0900
dc.identifier.issn	1942-0994
dc.identifier.uri	http://hdl.handle.net/10234/168417
dc.description.abstract	Naltrexone, an antagonist of 𝜇�-opioid receptors, is clinically used as adjuvant therapy of alcohol dishabituation. The aim of the present work was to test the effect of 1 mg/kg body weight of naltrexone to revert oxidative stress-related biochemical alterations, in the hippocampus and serum of chronic alcoholic adult rats. Malondialdehyde concentration was increased and glutathione peroxidase activity was decreased in hippocampus and serum of alcohol-treated rats. Naltrexone treatment restored these alterations. The in vitro antioxidant ability of Ntx could not justify these effects considering the doses used. Thus this apparent protective effect of Ntx can only be attributed to its pharmacological effects, as herein discussed.	ca_CA
dc.description.sponsorShip	Ministerio de Educacion y Ciencia SAF2010-21317 Universidad Catolica de Valencia "San Vicente Martir" 2012-029-001 Plan Nacional sobre Drogas 2010/059 AI/ICB-Santander 07/12	ca_CA
dc.format.extent	6 p.	ca_CA
dc.format.mimetype	application/pdf	ca_CA
dc.language.iso	eng	ca_CA
dc.publisher	Hindawi Publishing Corporation	ca_CA
dc.relation.isPartOf	Oxidative Medicine and Cellular Longevity Volume 2013 (2013), Article ID 296898	ca_CA
dc.rights	Copyright © 2013 Inmaculada Almansa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.	ca_CA
dc.rights	Atribución 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-sa/4.0/	*
dc.title	Naltrexone Reverses Ethanol-Induced Rat Hippocampal and Serum Oxidative Damage	ca_CA
dc.type	info:eu-repo/semantics/article	ca_CA
dc.identifier.doi	http://dx.doi.org/10.1155/2013/296898
dc.rights.accessRights	info:eu-repo/semantics/openAccess	ca_CA
dc.relation.publisherVersion	https://www.hindawi.com/journals/omcl/2013/296898/	ca_CA
dc.type.version	info:eu-repo/semantics/publishedVersion

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Copyright © 2013 Inmaculada Almansa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Excepto si se señala otra cosa, la licencia del ítem se describe como: Copyright © 2013 Inmaculada Almansa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.