Resistance training and redox homeostasis: Correlation with age-associated genomic changes

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comunitat-uji-handle:10234/9

comunitat-uji-handle2:10234/8017

comunitat-uji-handle3:10234/8616

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Title
Resistance training and redox homeostasis: Correlation with age-associated genomic changes
Author (s)
 Dimauro, Ivan;
 Scalabrin, Mattia;
 Fantini, Cristina;
 Graziolo, Elisa;
 Beltran Valls, Maria Reyes;
 Mercatelli, Neri;
 Parisi, Attilio;
 Sabatini, Stefania;
 Di Luigi, Luigi
Date
2016
Publisher
Elsevier
URI
http://hdl.handle.net/10234/167318
ISSN
2213-2317
Bibliographic citation
DIMAURO, Ivan, et al. Resistance training and redox homeostasis: Correlation with age-associated genomic changes. Redox biology, 2016, vol. 10, p. 34-44
Type
info:eu-repo/semantics/article
Publisher version
http://www.sciencedirect.com/science/article/pii/S2213231716300957
Subject
Abstract
Regular physical activity is effective as prevention and treatment for different chronic conditions related to the ageing processes. In fact, a sedentary lifestyle has been linked to a worsening of cellular ageing ... [+]
Regular physical activity is effective as prevention and treatment for different chronic conditions related to the ageing processes. In fact, a sedentary lifestyle has been linked to a worsening of cellular ageing biomarkers such as telomere length (TL) and/or specific epigenetic changes (e.g. DNA methylation), with increase of the propensity to aging-related diseases and premature death. Extending our previous findings, we aimed to test the hypothesis that 12 weeks of low frequency, moderate intensity, explosive-type resistance training (EMRT) may attenuate age-associated genomic changes. To this aim, TL, global DNA methylation, TRF2, Ku80, SIRT1, SIRT2 and global protein acetylation, as well as other proteins involved in apoptotic pathway (Bcl-2, Bax and Caspase-3), antioxidant response (TrxR1 and MnSOD) and oxidative damage (myeloperoxidase) were evaluated before and after EMRT in whole blood or peripheral mononuclear cells (PBMCs) of elderly subjects. Our findings confirm the potential of EMRT to induce an adaptive change in the antioxidant protein systems at systemic level and suggest a putative role of resistance training in the reduction of global DNA methylation. Moreover, we observed that EMRT counteracts the telomeres’ shortening in a manner that proved to be directly correlated with the amelioration of redox homeostasis and efficacy of training regime, evaluated as improvement of both muscle's power/strength and functional parameters. [-]
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Redox biology, 2016, vol. 10
Rights
info:eu-repo/semantics/openAccess
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© 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CCBY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Except where otherwise noted, this item's license is described as © 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CCBY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)