Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity
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Other documents of the author: Sorg, Barbara A.; Berretta, Sabina; Blacktop, Jordan; Fawcett, James W.; Kitagawa, Hiroshi; Kwok, Jessica C.F.; MIQUEL, MARTA
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
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Title
Casting a Wide Net: Role of Perineuronal Nets in Neural PlasticityAuthor (s)
Date
2016-11Publisher
Society for NeuroscienceBibliographic citation
SORG, Barbara A., et al. Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity. Journal of Neuroscience, 2016, vol. 36, no 45, p. 11459-11468.Type
info:eu-repo/semantics/articlePublisher version
http://www.jneurosci.org/content/36/45/11459Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around certain neurons in the CNS during development and control plasticity in the adult CNS. They appear to contribute to a wide range of ... [+]
Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around certain neurons in the CNS during development and control plasticity in the adult CNS. They appear to contribute to a wide range of diseases/disorders of the brain, are involved in recovery from spinal cord injury, and are altered during aging, learning and memory, and after exposure to drugs of abuse. Here the focus is on how a major component of PNNs, chondroitin sulfate proteoglycans, control plasticity, and on the role of PNNs in memory in normal aging, in a tauopathy model of Alzheimer's disease, and in drug addiction. Also discussed is how altered extracellular matrix/PNN formation during development may produce synaptic pathology associated with schizophrenia, bipolar disorder, major depression, and autism spectrum disorders. Understanding the molecular underpinnings of how PNNs are altered in normal physiology and disease will offer insights into new treatment approaches for these diseases. [-]
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Journal of Neuroscience 9 November 2016, 36 (45)Rights
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