Prenatal mercury exposure and birth outcomes
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Other documents of the author: Murcia, Mario; Ballester, Ferran; Enning, Ashley Michel; Iñiguez, Carmen; Valvi, Damaskini; Basterretxea, Mikel; Rebagliato, Marisa; Vioque, Jesus; Maruri, Maite; Tardon, Adonina; Riaño, Isolina; Vrijheid, Martine; Llop, Sabrina
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http://dx.doi.org/10.1016/j.envres.2016.07.003 |
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Title
Prenatal mercury exposure and birth outcomesAuthor (s)
Date
2016-11Publisher
ElsevierBibliographic citation
MURCIA, Mario; BALLESTER, Ferran; ENNING, Ashley Michel; IÑIGUEZ, Carmen; VALVI, Damaskini; BASTERRECHEA, Mikel; REBAGLIATO, Marisa; VIOQUE, Jesús; MARURI, Maite; TARDÓN, Adonina; RIAÑO-GALÁN, Isoline; VRIJHEID, Martine; LLOP, Sabrina. Prenatal mercury exposure and birth outcomes. Environmental research (2016), v. 151, pp. 11-20Type
info:eu-repo/semantics/articlePublisher version
http://www.sciencedirect.com/science/article/pii/S0013935116302857Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
Background: Results regarding the association between mercury exposure and anthropometry at birth, gestational length and placental weight are inconsistent, as is the role of seafood intake in these asso- ciations. ... [+]
Background: Results regarding the association between mercury exposure and anthropometry at birth, gestational length and placental weight are inconsistent, as is the role of seafood intake in these asso- ciations. Objective: We assessed whether prenatal mercury exposure is associated with anthropometry at birth, placental weight and gestational length in a population with a relatively high exposure to mercury from seafood consumption. Methods: Total mercury (T – Hg) was determined in cord blood from 1869 newborns with birth outcome measures, within the Spanish multicenter INMA cohort from 2004 to 2008. We adjusted cohort speci fi c linear and Cox regression models to evaluate the association between T – Hg and birth anthropometry (weight, length, and head circumference), placental weight and gestational length. Non-spontaneous labor was taken to be censoring in the survival analysis. Final estimates were obtained using meta- analysis. Results: Geometric mean T – Hg was 8.2 μ g/L. A doubling of T – Hg was associated with a 7.7 g decrease in placental weight (95% CI: 13.6, 1.8) and marginally with head circumference (beta: 0.052 cm, 95% CI: 0.109, 0.005). T – Hg was also inversely related to weight and length, although with weaker esti- mates. Mercury exposure was not associated with the length of gestation. The inverse relation between T – Hg and growth was enhanced when the intake of different seafood groups was adjusted for in the models. Conclusions: Prenatal mercury exposure may be associated with reduced placental and fetal growth. Confounding by fish intake should be considered when assessing these relationships. [-]
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Environmental research (2016), v. 151Rights
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info:eu-repo/semantics/restrictedAccess
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