MicroRNAs and Drinking: Association between the Pre-miR-27a rs895819 Polymorphism and Alcohol Consumption in a Mediterranean Population
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Other documents of the author: Barragán-Arnal, Rocío; Coltell, Oscar; Asensio, Eva Maria; Francés, Francesc; Sorlí, José V; Estruch, Ramon; Salas Huetos, Albert; Ordovás Muñoz, José M.; Corella, Dolores
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Title
MicroRNAs and Drinking: Association between the Pre-miR-27a rs895819 Polymorphism and Alcohol Consumption in a Mediterranean PopulationAuthor (s)
Date
2016Publisher
MDPIISSN
1661-6596; 1422-0067Bibliographic citation
Barragan, R., Coltell, O., Asensio, E. M., Frances, F., Sorlí, J.,V., Estruch, R., . . . Corella, D. (2016). MicroRNAs and drinking: Association between the pre-miR-27a rs895819 polymorphism and alcohol consumption in a mediterranean population. International Journal of Molecular Sciences, 17(8), 1338.Type
info:eu-repo/semantics/articlePublisher version
http://search.proquest.com/docview/1819310795?pq-origsite=summonVersion
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Abstract
Recently, microRNAs (miRNA) have been proposed as regulators in the different processes
involved in alcohol intake, and differences have been found in the miRNA expression profile
in alcoholics. However, no study ... [+]
Recently, microRNAs (miRNA) have been proposed as regulators in the different processes
involved in alcohol intake, and differences have been found in the miRNA expression profile
in alcoholics. However, no study has focused on analyzing polymorphisms in genes encoding
miRNAs and daily alcohol consumption at the population level. Our aim was to investigate the
association between a functional polymorphism in the pre-miR-27a (rs895819 A>G) gene and alcohol
consumption in an elderly population. We undertook a cross-sectional study of PREvención con
DIeta MEDiterránea (PREDIMED)-Valencia participants (n = 1007, including men and women aged
67 7 years) and measured their alcohol consumption (total and alcoholic beverages) through a
validated questionnaire. We found a strong association between the pre-miR-27a polymorphism
and total alcohol intake, this being higher in GG subjects (5.2 0.4 in AA, 5.9 0.5 in AG and
9.1 1.8 g/day in GG; padjusted = 0.019). We also found a statistically-significant association of the
pre-miR-27a polymorphism with the risk of having a high alcohol intake (>2 drinks/day in men
and >1 in women): 5.9% in AA versus 17.5% in GG; padjusted < 0.001. In the sensitivity analysis, this
association was homogeneous for sex, obesity and Mediterranean diet adherence. In conclusion,
we report for the first time a significant association between a miRNA polymorphism (rs895819) and
daily alcohol consumption. [-]
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International Journal of Molecular Sciences, 2016, vol. 17, núm. 8Rights
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