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Acute oral administration of low doses of methylphenidate targets calretinin neurons in the rat septal area
dc.contributor.author | García Avilés, Álvaro | |
dc.contributor.author | Albert Gasco, Hector | |
dc.contributor.author | Arnal Vicente, Isabel | |
dc.contributor.author | Elhajj, Ebtisam | |
dc.contributor.author | Sanjuán, Julio | |
dc.contributor.author | Sánchez-Pérez, Ana María | |
dc.contributor.author | Olucha-Bordonau, Francisco E | |
dc.date.accessioned | 2016-04-27T14:12:40Z | |
dc.date.available | 2016-04-27T14:12:40Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | García-Avilés Á, Albert-Gascó H, Arnal-Vicente I, Elhajj E, Sanjuan-Arias J, Sanchez-Perez AM and Olucha-Bordonau F (2015) Acute oral administration of low doses of methylphenidate targets calretinin neurons in the rat septal area. Front. Neuroanat. 9:33. doi: 10.3389/fnana.2015.00033 | ca_CA |
dc.identifier.issn | 1662-5129 | |
dc.identifier.uri | http://hdl.handle.net/10234/159005 | |
dc.description.abstract | Methylphenidate (MPD) is a commonly administered drug to treat children suffering from attention deficit hyperactivity disorder (ADHD). Alterations in septal driven hippocampal theta rhythm may underlie attention deficits observed in these patients. Amongst others, the septo-hippocampal connections have long been acknowledged to be important in preserving hippocampal function. Thus, we wanted to ascertain if MPD administration, which improves attention in patients, could affect septal areas connecting with hippocampus. We used low and orally administered MPD doses (1.3, 2.7 and 5 mg/Kg) to rats what mimics the dosage range in humans. In our model, we observed no effect when using 1.3 mg/Kg MPD; whereas 2.7 and 5 mg/Kg induced a significant increase in c-fos expression specifically in the medial septum (MS), an area intimately connected to the hippocampus. We analyzed dopaminergic areas such as nucleus accumbens and striatum, and found that only 5 mg/Kg induced c-fos levels increase. In these areas tyrosine hydroxylase correlated well with c-fos staining, whereas in the MS the sparse tyrosine hydroxylase fibers did not overlap with c-fos positive neurons. Double immunofluorescence of c-fos with neuronal markers in the septal area revealed that co-localization with choline acethyl transferase, parvalbumin, and calbindin with c-fos did not change with MPD treatment; whereas, calretinin and c-fos double labeled neurons increased after MPD administration. Altogether, these results suggest that low and acute doses of methylphenidate primary target specific populations of caltretinin medial septal neurons. | ca_CA |
dc.format.extent | 12 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Frontiers Media | ca_CA |
dc.relation.isPartOf | Front. Neuroanat., 23 March 2015 | ca_CA |
dc.rights | This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission. Copyright © 2015 García-Avilés, Albert-Gascó, Arnal-Vicente, Elhajj, Sanjuan-Arias, Sanchez-Perez and Olucha-Bordonau. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | ca_CA |
dc.rights | Attribution 4.0 Spain | * |
dc.rights.uri | http://creativecommons.org/licenses/by-sa/4.0/ | * |
dc.subject | ADHD | ca_CA |
dc.subject | Methylphenidate | ca_CA |
dc.subject | Catecholamines | ca_CA |
dc.subject | Calcium binding proteins | ca_CA |
dc.subject | Theta rhythm | ca_CA |
dc.title | Acute oral administration of low doses of methylphenidate targets calretinin neurons in the rat septal area | ca_CA |
dc.title.alternative | Acute oral administration of low doses of methylphenidate targets calretinin neurons in the rat septal area | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.3389/fnana.2015.00033 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | http://journal.frontiersin.org/article/10.3389/fnana.2015.00033/full | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion |
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Excepto si se señala otra cosa, la licencia del ítem se describe como: This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission.
Copyright © 2015 García-Avilés, Albert-Gascó, Arnal-Vicente, Elhajj, Sanjuan-Arias, Sanchez-Perez and Olucha-Bordonau. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.