Chronic Cocaine Effects in Retinal Metabolism and Electrophysiology: Treatment with Topiramate
Impact
Scholar |
Other documents of the author: Sánchez-Villarejo, María V.; López-Pedrajas, Rosa; Sánchez Vallejo, Violeta; Genovés, José M.; Muriach Saurí, María; Barcia, Jorge M; Romero, Francisco J.
Metadata
Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
comunitat-uji-handle4:
INVESTIGACIONThis resource is restricted
http://dx.doi.org/10.3109/02713683.2013.850097 |
Metadata
Title
Chronic Cocaine Effects in Retinal Metabolism and Electrophysiology: Treatment with TopiramateAuthor (s)
Date
2014Publisher
Informa HealthcareISSN
0271-3683; 1460-2202Type
info:eu-repo/semantics/articlePublisher version
http://www.tandfonline.com/doi/abs/10.3109/02713683.2013.850097Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
Purpose: Cocaine abuse is a major public health problem with multiple-related complications. Indeed, cocaine can affect almost every organ of the human body, but little is known about its effects on the visual system. ... [+]
Purpose: Cocaine abuse is a major public health problem with multiple-related complications. Indeed, cocaine can affect almost every organ of the human body, but little is known about its effects on the visual system. The main purpose of this work was to study if topiramate was able to reverse changes in retinal metabolism and retinal function induced by chronic cocaine exposure in adult rats.
Materials and methods: Sixteen Wistar rats were treated with a daily oral dose of cocaine during 36 days. Sixteen rats receiving NaCl 0.9% served as controls. Eight control and eight cocaine animals were administered topiramate from day 18 to day 36 of the experiment. Malondialdehyde (MDA), glutathione (GSH) and glutamate content, as well as glutathione peroxidase (GPx) activity in retina tissue homogenates were determined. Retinal function was assessed by electroretinogram (ERG).
Results: Glutamate concentration was increased in the retinas of cocaine-treated rats. No changes in oxidative stress parameters were observed in the retinas of cocaine-treated rats when compared with the control ones. Cocaine induced a decrease in the a-wave and b-wave ERG amplitude. The administration of topiramate reversed cocaine-induced increase in glutamate concentration and had little effect on a-wave and b-wave ERG amplitude. Topiramate, a drug used during the last decade for the treatment of epileptic seizures, is able to reverse the cocaine-induced alterations observed in retinal glutamate concentration.
Conclusions: We can conclude that retinal glutamate metabolism and function may be affected by exposure to cocaine. We confirm that topiramate, a treatment recently proposed for cocaine dependence, is also able to recover partially cocaine-induced changes in the retina. [-]
Is part of
Current Eye Research, 2014, vol. 39, núm. 5Rights
Copyright © Informa Healthcare 2014
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/restrictedAccess
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/restrictedAccess
This item appears in the folowing collection(s)
- MED_Articles [637]