Tuning Chelation by the Surfactant-Like Peptide A(6)H Using Predetermined pH
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Otros documentos de la autoría: Castelletto, Valeria; Hamley, Ian W.; Segarra Maset, María Dolores; Berdugo Gumbau, Cristina; Miravet, Juan; Escuder, Beatriu; Seitsonen, J.; Ruokolainen, J.
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http://dx.doi.org/10.1021/bm401640j |
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Título
Tuning Chelation by the Surfactant-Like Peptide A(6)H Using Predetermined pHAutoría
Fecha de publicación
2014Editor
American Chemical SocietyISSN
1525-7797Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://pubs.acs.org/doi/full/10.1021/bm401640jPalabras clave / Materias
Resumen
We examine the self-assembly of a peptide A6H comprising a hexa-alanine sequence A6 with a histidine (H) “head group”, which chelates Zn2+ cations. We study the self-assembly of A6H and binding of Zn2+ ions in ZnCl2 ... [+]
We examine the self-assembly of a peptide A6H comprising a hexa-alanine sequence A6 with a histidine (H) “head group”, which chelates Zn2+ cations. We study the self-assembly of A6H and binding of Zn2+ ions in ZnCl2 solutions, under acidic and neutral conditions. A6H self-assembles into nanotapes held together by a β-sheet structure in acidic aqueous solutions. By dissolving A6H in acidic ZnCl2 solutions, the carbonyl oxygen atoms in A6H chelate the Zn2+ ions and allow for β-sheet formation at lower concentrations, consequently reducing the onset concentration for nanotape formation. A6H mixed with water or ZnCl2 solutions under neutral conditions produces short sheets or pseudocrystalline tapes, respectively. The imidazole ring of A6H chelates Zn2+ ions in neutral solutions. The internal structure of nanosheets and pseudocrystalline sheets in neutral solutions is similar to the internal structure of A6H nanotapes in acidic solutions. Our results show that it is possible to induce dramatic changes in the self-assembly and chelation sites of A6H by changing the pH of the solution. However, it is likely that the amphiphilic nature of A6H determines the internal structure of the self-assembled aggregates independent from changes in chelation. [-]
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Biomacromolecules, 2014, 15 (2)Derechos de acceso
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