Involvement of nitric oxide in the mitochondrial action of efavirenz: a differential effect on neurons and glial cells
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Other documents of the author: Apostolova, Nadezda; Funes, Haryes A.; Blas García, Ana; Alegre, Fernando; Polo, Míriam; Esplugues Mota, Juan V.
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Title
Involvement of nitric oxide in the mitochondrial action of efavirenz: a differential effect on neurons and glial cellsAuthor (s)
Date
2014-12Publisher
Oxford University PressBibliographic citation
APOSTOLOVA, Nadezda, et al. Involvement of nitric oxide in the mitochondrial action of efavirenz: a differential effect on neurons and glial cells. Journal of Infectious Diseases, 2015, 211.12: 1953-1958.Type
info:eu-repo/semantics/articlePublisher version
http://jid.oxfordjournals.org/content/211/12/1953.shortSubject
Abstract
The anti-human immunodeficiency virus (HIV) drug efavirenz (EFV) alters mitochondrial function in cultured neurons and glial cells. Nitric oxide (NO) is a mediator of mitochondrial dysfunction associated with HIV ... [+]
The anti-human immunodeficiency virus (HIV) drug efavirenz (EFV) alters mitochondrial function in cultured neurons and glial cells. Nitric oxide (NO) is a mediator of mitochondrial dysfunction associated with HIV central nervous system symptoms. We show that EFV promotes inducible nitric oxide synthase (iNOS) expression in cultured glial cells and generated NO undermines their mitochondrial function, as inhibition of NOS partially reverses this effect. EFV inhibits mitochondrial Complex I in both neurons and glia; however, when the latter cells are treated for longer periods, other mitochondrial complexes are also affected in accordance with the increased NO production. These findings shed light on the mechanisms responsible for the frequent EFV-associated neurotoxicity. [-]
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Journal of Infectious Diseases, 2015, 211.12Rights
© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved
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