Magnitude of pharmacological nonadherence in hypertensive patients taking antihypertensive medication from a community pharmacy in Spain
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Other documents of the author: Perseguer Torregrosa, Zeneida; Orozco Beltrán, Domingo; Gil-Guillén, Vicente F; Pita Fernández, Salvador; Carratalá Munuera, Concepción; Pallarés-Carratalá, Vicente; López Pineda, Adriana
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Title
Magnitude of pharmacological nonadherence in hypertensive patients taking antihypertensive medication from a community pharmacy in SpainAuthor (s)
Date
2014-12Publisher
Academy of Managed Care PharmacyISSN
1083-4087Bibliographic citation
PERSEGUER-TORREGROSA, Zeneida, et al. Magnitude of Pharmacological Nonadherence in Hypertensive Patients Taking Antihypertensive Medication from a Community Pharmacy in Spain. J Manag Care Pharm, 2014, 20.12: 1217-25.Type
info:eu-repo/semantics/articlePublisher version
http://www.amcp.org/WorkArea/DownloadAsset.aspx?id=18842Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
BACKGROUND: The most common factor associated with poor control of
hypertension is treatment nonadherence to antihypertensive drug therapy.
OBJECTIVE: To measure drug nonadherence and associated factors in
pharma ... [+]
BACKGROUND: The most common factor associated with poor control of
hypertension is treatment nonadherence to antihypertensive drug therapy.
OBJECTIVE: To measure drug nonadherence and associated factors in
pharmacologically treated hypertensive patients.
METHODS: A prospective observational study was carried out from March
2007 to August 2009 at a community pharmacy in Spain. A pharmacist invited
a convenience sample of hypertensive patients aged 50 years and older
taking antihypertensive medication for at least 3 months prior to participate
in the study. Drug nonadherence was analyzed by 3 separate methods: pill
count, as the gold standard method, and Haynes-Sackett and Morisky-Green
questionnaires. A descriptive analysis of drug nonadherence and variables
associated with nonadherence was performed. Logistic regression models
were used to determine the variables associated with nonadherence.
RESULTS: Data were recorded from 419 patients. The drug nonadherence
ratio varied depending on the method used: 62.8% by pill count, 3.1%
by the Haynes-Sackett self-report test, and 36% according to the
Morisky-Green test. In the multivariate model, the variable associated
with a decrease in drug nonadherence was years of known hypertension
(OR=0.962, 95% CI=0.937-0.988), and the variables associated with
an increase in drug nonadherence were loose-pill combination therapy
versus fixed-dose combination therapy or monotherapy (OR=4.099, 95%
CI=2.494-6.757) and good perception of quality of life (OR=1.276, 95%
CI=1.109-1.471).
CONCLUSIONS: The magnitude of drug nonadherence varies depending on
the method of measurement. The pill count method (reference method)
revealed that 2 out of 3 patients with hypertension did not have good
adherence. This study highlights the lack of antihypertensive drug adherence
and the pharmacist’s ability to detect the ass [-]
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J Manag Care Pharm, 2014, 20.12Rights
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