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Treatment adherence and other patient-reported outcomes as cost determinants in multiple sclerosis: a review of the literature
dc.contributor.author | Lizán, Luis | |
dc.contributor.author | Comellas, Marta | |
dc.contributor.author | Paz, Silvia | |
dc.contributor.author | Poveda, José Luis | |
dc.contributor.author | Meletiche, Dennis M. | |
dc.contributor.author | Polanco, Carlos | |
dc.date.accessioned | 2015-05-29T14:51:25Z | |
dc.date.available | 2015-05-29T14:51:25Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1177-889X | |
dc.identifier.issn | 1177-889X | |
dc.identifier.uri | http://hdl.handle.net/10234/122243 | |
dc.description.abstract | Background: Treatment adherence is one of the key factors for achieving optimal clinical outcomes. In order to assess costs related to adherence to, and persistence and compliance with, disease-modifying therapies (DMTs) in patients with multiple sclerosis (MS), a narrative review of the literature was performed. Satisfaction with and preference for DMTs and their delivery devices were also assessed, as both can have an influence on patients’ adherence and persistence. Methods: Electronic databases (MEDLINE, PubMed, Google Scholar, congress proceedings) were searched to identify publications analyzing MS costs related to adherence, persistence, satisfaction, and preferences for MS treatments. Bibliographic references were hand searched. English or Spanish studies published between January 2007 and January 2013 were selected. Results: A total of 398 titles were identified, of which 12 met the inclusion criteria. Six studies evaluated the impact of adherence, persistence, and compliance on treatment costs; four publications analyzed satisfaction with DMTs; and two assessed treatment preferences based on attributes of the delivery device. Increased adherence and persistence were associated with better clinical outcomes, leading to lower relapse risk (odds ratio [OR]: 0.71; 95% confidence interval [CI]: 0.59–0.85) and a decrease in health care resource use, such as MS-related hospitalizations (OR: 0.63; 95% CI: 0.47–0.83) and emergency department visits (OR: 0.80; 95% CI: 0.60–1.07). This reduction in resource use led to a patient/year total cost reduction (excluding DMT costs) of up to 22%. Conclusion: This review highlights the importance of ensuring adequate adherence in MS patients through treatments and devices better tailored to patients’ needs that could enhance clinical outcomes and reduce MS costs. Understanding the factors underlying satisfaction and compliance with treatment and patients’ preference for certain therapies could help in the development of strategies that can improve adherence. | ca_CA |
dc.format.extent | 12 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Dove Medical Press | ca_CA |
dc.relation.isPartOf | Patient Preference and Adherence 2014:8 | ca_CA |
dc.rights | © 2014 Lizán et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v4.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/4.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php | ca_CA |
dc.rights | http://creativecommons.org/licenses/by-nc/4.0/es/ | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject | multiple sclerosis | ca_CA |
dc.subject | adherence | ca_CA |
dc.subject | satisfaction | ca_CA |
dc.subject | delivery devices | ca_CA |
dc.subject | costs | ca_CA |
dc.title | Treatment adherence and other patient-reported outcomes as cost determinants in multiple sclerosis: a review of the literature | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.2147/PPA.S67253 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | http://www.dovepress.com/patient-preference-and-adherence-journal | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion |
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Excepto si se señala otra cosa, la licencia del ítem se describe como: © 2014 Lizán et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v4.0)
License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/4.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php