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Fabrication of gold nanoparticles in Therminol VP-1 by laser ablation and fragmentation with fs pulses
(IOP Science, 2014-10-22)
This letter reports on a physical method to produce highly pure, size-controlled and well-dispersed spherical gold nanoparticles (NPs) in Therminol VP-1 by pulsed laser ablation in liquids (PLAL) using a 30 fs Ti:Sapphire ...
Peptidyl nitroalkene inhibitors of main protease rationalized by computational and crystallographic investigations as antivirals against SARS-CoV-2
(Springer Nature, 2024-01-18)
The coronavirus disease 2019 (COVID-19) pandemic continues to represent a global public
health issue. The viral main protease (Mpro) represents one of the most attractive targets for
the development of antiviral drugs. ...
Impact of the Warhead of Dipeptidyl Keto Michael Acceptors on the Inhibition Mechanism of Cysteine Protease Cathepsin L
(American Chemical Society, 2023-10-03)
Cathepsin L (CatL) is a lysosomal cysteine protease whose activity has been related to several human pathologies. However, although preclinical trials using CatL inhibitors were promising, clinical trials have been ...
Impact of the Recognition Part of Dipeptidyl Nitroalkene Compounds on the Inhibition Mechanism of Cysteine Proteases Cruzain and Cathepsin L
(American Chemical Society, 2023-05-05)
Cysteine proteases (CPs) are an important class of enzymes, many of which are responsible for several human diseases. For instance, cruzain of protozoan parasite Trypanosoma cruzi is responsible for the Chagas disease, ...
Elucidating the Dual Mode of Action of Dipeptidyl Enoates in the Inhibition of Rhodesain Cysteine Proteases
(Wiley, 2021-04-14)
A computational study of the two possible inhibition mechanisms of rhodesain cysteine protease by the dipeptidyl enoate Cbz-Phe-Leu-CH=CH−CO2C2H5 has been carried out by means of molecular dynamics simulations with hybrid ...