Degradation of perineuronal nets in the cerebellum to prevent relapse of drug seeking
Metadata
Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/29747
comunitat-uji-handle3:10234/162741
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TESISMetadata
Title
Degradation of perineuronal nets in the cerebellum to prevent relapse of drug seekingAuthor (s)
Director
MIQUEL, MARTADoctoral Studies
Programa de Doctorat en CiènciesResponsible entity
Universitat Jaume I. Escola de DoctoratDate of defense
2023-03-03Description
Doctorat internacional
Publisher
Universitat Jaume ISubject
Keywords
Pages
196 p.Abstract
Drug addiction can be associated with the ability of certain substances to hijack natural learning and memory mechanisms. This thesis focuses on the study and manipulation of cerebellar perineuronal nets (PNNs) following ... [+]
Drug addiction can be associated with the ability of certain substances to hijack natural learning and memory mechanisms. This thesis focuses on the study and manipulation of cerebellar perineuronal nets (PNNs) following cocaine self-administration. These structures regulate synaptic architecture and have been related with learning, memory and addiction. Our results show that cocaine self-administration, in an extended access pattern, dynamically regulates plasticity conditions in the cerebellum during withdrawal and increases the expression of PNNs after prolonged abstinence. This is consistent with the observed expression levels of essential components of PNNs. These results support the theory that PNNs around Golgi interneurons are necessary mechanisms for the persistence of drug-induced memories and their regulation may be linked to their stabilisation. [-]
Rights
L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-nc-sa/4.0/
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess