Browsing UJI: Investigación by Source "European Journal of Medicinal Chemistry (2018), v. 150"
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Arylureas derived from colchicine: Enhancement of colchicine oncogene downregulation activity
Elsevier (2018-04-25)Our efforts to get therapeutically useful colchicine derivatives for the treatment of cancer have led us to synthetize and biologically evaluate twenty-seven N,N′-disubstituted ureas containing a colchicine moiety and an ... -
Effects on tubulin polymerization and down-regulation of c-Myc, hTERT and VEGF genes by colchicine haloacetyl and haloaroyl derivatives
Elsevier (2018-04-25)Several colchicine analogues in which the N-acetyl residue has been replaced by haloacetyl, cyclohexylacetyl, phenylacetyl and various aroyl moieties have been synthesized. The cytotoxic activities of the synthesized ...