Browsing UJI: Investigación by Author "e75ef02c-bbb1-4558-964a-3f25101d0c56"
Now showing items 1-20 of 25
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Association between several immune response-related genes and the effectiveness of biological treatments in patients with moderate-to-severe psoriasis
Loras Monfort, Alba; Gil-Barrachina, Marta; Hernando, Barbara; Pérez-Pastor, Gemma María; Martinez-Domenech, Alvaro; Mahiques, Laura; PITARCH BORT, GERARD; Valcuende-Cavero, Francisca; Ballester, Rosa; Marques-Torrejon, Maria Angeles; Martinez-Cadenas, Conrado Wiley (2024-01-04)Biological therapies are safer and more effective against psoriasis than conventional treatments. Even so, 30–50% of psoriatic patients show an inadequate response, which is associated with individual genetic heterogeneity. ... -
Association of TYR SNP rs1042602 with Melanoma Risk and Prognosis
Sevilla Mambrilla, Arrate; Sánchez-Diez, Ana; Cobo Sustacha, Sofía; Izagirre Arribalzaga, Neskuts; Martinez-Cadenas, Conrado; Marti, Rosa M; Puértolas, Teresa; De Unamuno Bustos, Blanca; Bañuls, José; Izu, Rosa; Gardeazabal, Jesús; Asumendi, Aintzane; Boyano, María D.; Alonso, Santos MDPI (2023)Cutaneous melanoma is the most aggressive of skin tumors. In order to discover new biomarkers that could help us improve prognostic prediction in melanoma patients, we have searched for germline DNA variants associated ... -
Comparison of the transcriptional profiles of melanocytes from dark and light skinned individuals under basal conditions and following ultraviolet-b irradiation
López, Saioa; Smith-Zubiaga, I.; García de Galdeano, Alicia; Boyano, Dolores; García, Oscar; Gardeazábal, Jesús; Martinez-Cadenas, Conrado; Izagirre, Neskuts; de la Rúa, Concepción; Alonso, Santos Public Library of Science (2015)We analysed the whole-genome transcriptional profile of 6 cell lines of dark melanocytes (DM) and 6 of light melanocytes (LM) at basal conditions and after ultraviolet-B (UVB) radiation at different time points to investigate ... -
Enhancing Prostate Tumor Biobanking Reliability with Improved Sampling Technique and Histological Characterization
Giner Moreno, Edu; Quereda Flores, Francisco; Hernández , Josselyn Andrea; Amigo Moreno, Raquel; Perez Ruiz, María Dolores; Carcelén López, Aileen; Rocher Benlloch, Jorge; Molió Sanchís, Pilar; Casares Calzada, Adrián; Marqués-Torrejón, María Ángeles; Martinez-Cadenas, Conrado; Ruiz-Cerdá, José Luis; Loras Monfort, Alba; Ramos Soler, David MyJove Corporation (2023-11-17)Acquiring fresh and well-characterized tumor tissue samples is critical for conducting high-quality "omics" studies. However, it can be particularly challenging in the context of prostate cancer (PC) due to the unique ... -
Factores de riesgo asociados a padecer cáncer de piel de células basales y escamosas en el Mediterráneo
Gil-Barrachina, Marta; Hernando, Barbara; Martinez-Cadenas, Conrado Publicacions de la Universitat Jaume I. Servei de Comunicació i Publicacions (2020)Introducción: Los cánceres de células basales (BCC) y de células escamosas (SCC), clasificados como cánceres cutáneos no-melanoma, son los de mayor incidencia en todo el mundo. Los principales factores etiológicos ... -
Gender and eye colour prediction discrepancies: A reply to criticisms (letter)
Martinez-Cadenas, Conrado; Peña Chilet, María; Llorca-Cardeñosa, Marta J.; Cervera, Raimundo; Ibarrola-Villava, Maider; Ribas, Gloria Elsevier (2014)Letter to the editor: In a letter published in this same issue, Liu et al. reply to a recently published article by us contesting the main conclusion of our original paper, namely, that gender is a factor that contributes to ... -
Gender is a major factor explaining discrepancies in eye colour prediction based on HERC2/OCA2 genotype and the IrisPlex model
Martinez-Cadenas, Conrado; Peña Chilet, María; Ibarrola-Villava, Maider; Ribas, Gloria Elsevier (2013)In recent years, several studies have greatly increased our understanding of the genetic basis underlying human eye colour variation. A large percentage of the eye colour diversity present in humans can already be genetically ... -
Genetic 3’UTR variation is associated with human pigmentation characteristics and sensitivity to sunlight
Hernando, Barbara; Peña-Chilet, Maria; Ibarrola-Villava, Maider; Martín González, Manuel; Gómez Fernández, Cristina; Ribas, Gloria; Martinez-Cadenas, Conrado Wiley (2017-10)Sunlight exposure induces signalling pathways leading to the activation of melanin synthesis and tanning response. MicroRNAs (miRNAs) can regulate the expression of genes involved in pigmentation pathways by binding to the ... -
Genetic determinants of freckle occurrence in the Spanish population: Towards ephelides prediction from human DNA samples
Hernando, Barbara; Ibáñez Gual, Maria Victoria; Deserio Cuesta, Julio Alberto; Soria Navarro, Raquel; Vilar Sastre, Inca; Martinez-Cadenas, Conrado Elsevier (2018-03)Prediction of human pigmentation traits, one of the most differentiable externally visible characteristics among individuals, from biological samples represents a useful tool in the field of forensic DNA phenotyping. ... -
Genetic variants associated with skin photosensitivity in a southern European population from Spain
Hernando, Barbara; Sanz-Page, Elena; PITARCH BORT, GERARD; Mahiques, Laura; Valcuende-Cavero, Francisca; Martinez-Cadenas, Conrado Wiley (2018)Background/Purpose: Recent GWAS studies, mostly performed in populations of North European origin, have identified the genetic loci associated with pigmentation, sun sensitivity, freckling and skin cancer ... -
Genetic variants in PARP1 (rs3219090) and IRF4 (rs12203592) genes associated with melanoma susceptibility in a Spanish population
Peña Chilet, María; Blanquer Maceiras, Maite; Ibarrola-Villava, Maider; Martinez-Cadenas, Conrado; Martín González, Manuel; Gómez Fernández, Cristina; Mayor, Matías; Avilés, Juan Antonio; Lluch , Ana; Ribas, Gloria BioMed Central (2013-03)Background Few high penetrance genes are known in Malignant Melanoma (MM), however, the involvement of low-penetrance genes such as MC1R, OCA2, ASIP, SLC45A2 and TYR has been observed. Lately, genome-wide association ... -
Identificación de variantes genéticas asociadas a la sensibilidad solar
Deserio Cuesta, Julio Alberto; Soria Navarro, Raquel; Vilar Sastre, Inca; Hernando, Barbara; Martinez-Cadenas, Conrado Publicacions de la Universitat Jaume I. Servei de Comunicació i Publicacions (2018)Introducción: La sensibilidad a la radiación ultravioleta está determinada por característicaspigmentarias influenciadas por varios genes. Ciertos rasgos de la pigmentación,como tener un color de piel claro, tener muchas ... -
Involvement of ANXA5 and ILKAP in Susceptibility to Malignant Melanoma
Santos, Alonso; Ribas, Gloria; Ibarrola-Villava, Maider; Peña Chilet, María; Martinez-Cadenas, Conrado; Gardeazabal, Jesús; Careaga, Jesús María; Pérez-Yarza, Gorka; Sánchez-Díez, Ana; Ratón-Nieto, Juan Antonio; Arroyo-Berdgo, Yoana; Carretero, Gregorio; Martín González, Manuel; Gómez Fernández, Cristina; Nagore, Eduardo; Asumendi, Aintzane; Boyano, Dolores Public Library of Science (2014)Single nucleotide-polymorphisms (SNPs) are a source of diversity among human population, which may be responsible for the different individual susceptibility to diseases and/or response to drugs, among other phenotypic ... -
Long telomere length and a TERT-CLPTM1 locus polymorphism association with melanoma risk
Llorca-Cardeñosa, Marta J.; Peña Chilet, María; Mayor, Matías; Gómez Fernández, Cristina; Casado, Beatriz; Martín González, Manuel; Carretero, Gregorio; Lluch , Ana; Martinez-Cadenas, Conrado; Ibarrola-Villava, Maider; Ribas, Gloria Elsevier (2014)Telomere length has been associated with the development of cancer. Studies have shown that shorter telomere length may be related to a decreased risk of cutaneous melanoma. Furthermore, deregulation of the telomere-maintaining ... -
Neural Stem Cells as Potential Glioblastoma Cells of Origin
Loras Monfort, Alba; Gonzalez Bonet, Luis Germán; Gutierrez-Arroyo, Julia L.; Martinez-Cadenas, Conrado; Marques-Torrejon, Maria Angeles MDPI (2023)Glioblastoma multiforme (GBM) is the most malignant brain tumor in adults and it remains incurable. These tumors are very heterogeneous, resistant to cytotoxic therapies, and they show high rates of invasiveness. Therefore, ... -
¿Qué papel juega la exposición solar en el desarrollo del cáncer de piel? El efecto de la radiación ultravioleta en la acumulación de mutaciones somáticas en piel sana
Moreno Illueca, Rocío; Herrero Rodríguez, Germán; Hernando, Barbara; Martinez-Cadenas, Conrado Publicacions de la Universitat Jaume I. Servei de Comunicació i Publicacions (2020)Introducción: El cáncer cutáneo surge a resultas de alteraciones genómicas en células de la piel, normalmente a consecuencia de la exposición a radiación solar. La detección de mutaciones somáticas en células normales puede ... -
¿Qué repercusión a nivel fisiológico puede tener realizar una carrera de ultratrail? Análisis de la alteración de biomarcadores de daño cardíaco y muscular en corredores amateurs de ultratrail
Collado Andrés, Claudia; Hernando, Barbara; Hernando, Carlos; Martinez-Cadenas, Conrado Publicacions de la Universitat Jaume I. Servei de Comunicació i Publicacions (2020)La participación en ultratrails ha incrementado significativamente su popularidad en los últimos años. Debido a las características extremas de estas pruebas y a las consecuencias que pueden tener sobre la salud de ... -
Sex and MC1R variants in human pigmentation: Differences in tanning ability and sensitivity to sunlight between sexes
Hernando, Barbara; Ibarrola-Villava, Maider; Peña Chilet, María; Alonso, Santos; Ribas, Gloria; Martinez-Cadenas, Conrado Elsevier (2016) -
Sex-specific genetic effects associated with pigmentation, sensitivity to sunlight, and melanoma in a population of Spanish origin
Hernando, Barbara; Ibarrola-Villava, Maider; Fernández, Lara P.; Peña Chilet, María; Llorca-Cardeñosa, Marta J.; Oltra, Sara S.; Alonso, Santos; Boyano, Dolores; Martinez-Cadenas, Conrado; Ribas, Gloria BioMed Central (2016-03)Background Human pigmentation is a polygenic quantitative trait with high heritability. In addition to genetic factors, it has been shown that pigmentation can be modulated by oestrogens and androgens via up- or ... -
Simultaneous purifying selection on the ancestral MC1R allele and positive selection on the melanoma-risk allele V60L in South Europeans
Martinez-Cadenas, Conrado; López, Saioa; Ribas, Gloria; Flores, Carlos; García, Oscar; Sevilla, Arrate; Smith-Zubiaga, I.; Ibarrola-Villava, Maider; Pino-Yanes, M .; Gardeazabal, Jesús; Boyano, Dolores; García de Galdeano, Alicia; Izagirre, Neskuts; de la Rúa, Concepción; Alonso, Santos Oxford University Press (2013)In humans, the geographical apportionment of the coding diversity of the pigmentary locus melanocortin-1 receptor (MC1R) is, unusually, higher in Eurasians than in Africans. This atypical observation has been interpreted ...