Visualitza UJI: Investigación per autoria "e34663e2-c472-47e6-8e7e-3d9665180f2a"
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A ciliopathy complex builds distal appendages to initiate ciliogenesis
Kumar, Dhivya; Rains, Addison; Herranz-Pérez, Vicente; Lü, Quanlong; Shi, Xiaoyu; Swaney, Danielle; Stevenson, Erica; Krogan, Nevan; Huang, Bo; Westlake, Christopher; García-Verdugo, Jose Manuel; Yoder, Bradley; Reiter, Jeremy Rockefeller University Press (2021-07-09)Cells inherit two centrioles, the older of which is uniquely capable of generating a cilium. Using proteomics and superresolved imaging, we identify a module that we term DISCO (distal centriole complex). The DISCO components ... -
Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis
Hall, Emma; Kumar, Dhivya; Prosser, Suzanna; Yeyati, Patricia; Herranz-Pérez, Vicente; García-Verdugo, Jose Manuel; rose, lorraine; McKie, Lisa; Dodd, Daniel; Tennant, Peter; Megaw, Roly; Murphy, Laura; Ferreira, Marisa; Grimes, Graeme; Williams, Lucy; Quidwai, Tooba; Pelletier, Laurence; Reiter, Jeremy; Mill, Pleasantine eLife Sciences Publications (2023-02-15)Centrosomes are orbited by centriolar satellites, dynamic multiprotein assemblies nucleated by Pericentriolar Material 1 (PCM1). To study the requirement for centriolar satellites, we generated mice lacking PCM1, a crucial ...