Brain Changes in Long-Term Zen Meditators Using Proton Magnetic Resonance Spectroscopy and Diffusion Tensor Imaging: A Controlled Study
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Otros documentos de la autoría: Fayed, Nicolás; López-del-Hoyo, Yolanda; Andrés, Eva; Serrano Blanco, Antoni; Bellón, Juan; Aguilar, Keyla; Cebolla Marti, Ausias; Garcia-Campayo, Javier
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Brain Changes in Long-Term Zen Meditators Using Proton Magnetic Resonance Spectroscopy and Diffusion Tensor Imaging: A Controlled StudyAutoría
Fecha de publicación
2013Editor
Public Library of ScienceISSN
1932-6203Cita bibliográfica
Fayed N, Lopez del Hoyo Y, Andres E, Serrano-Blanco A, Bello´n J, et al. (2013) Brain Changes in Long-Term Zen Meditators Using Proton Magnetic Resonance Spectroscopy and Diffusion Tensor Imaging: A Controlled Study. PLoS ONE 8(3): e58476. doi:10.1371/journal.pone.0058476Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjou ...Versión
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Introduction: This work aimed to determine whether 1
H magnetic resonance imaging (MRI), magnetic resonance
spectroscopy (MRS), diffusion-weighted imaging (DWI) and diffusion tensor imaging (DTI) are correlated with ... [+]
Introduction: This work aimed to determine whether 1
H magnetic resonance imaging (MRI), magnetic resonance
spectroscopy (MRS), diffusion-weighted imaging (DWI) and diffusion tensor imaging (DTI) are correlated with years of
meditation and psychological variables in long-term Zen meditators compared to healthy non-meditator controls.
Materials and Methods: Design. Controlled, cross-sectional study. Sample. Meditators were recruited from a Zen Buddhist
monastery. The control group was recruited from hospital staff. Meditators were administered questionnaires on anxiety,
depression, cognitive impairment and mindfulness. 1
H-MRS (1.5 T) of the brain was carried out by exploring four areas: both
thalami, both hippocampi, the posterior superior parietal lobule (PSPL) and posterior cingulate gyrus. Predefined areas of
the brain were measured for diffusivity (ADC) and fractional anisotropy (FA) by MR-DTI.
Results: Myo-inositol (mI) was increased in the posterior cingulate gyrus and Glutamate (Glu), N-acetyl-aspartate (NAA) and
N-acetyl-aspartate/Creatine (NAA/Cr) was reduced in the left thalamus in meditators. We found a significant positive
correlation between mI in the posterior cingulate and years of meditation (r = 0.518; p= .019). We also found significant
negative correlations between Glu (r =20.452; p= .045), NAA (r =20.617; p= .003) and NAA/Cr (r =20.448; P = .047) in the
left thalamus and years of meditation. Meditators showed a lower Apparent Diffusion Coefficient (ADC) in the left posterior
parietal white matter than did controls, and the ADC was negatively correlated with years of meditation (r =20.4850,
p= .0066).
Conclusions: The results are consistent with the view that mI, Glu and NAA are the most important altered metabolites. This
study provides evidence of subtle abnormalities in neuronal function in regions of the white matter in meditators. [-]
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PLoS ONE, 2013, Volume 8, Issue 3, Article number e58476Derechos de acceso
info:eu-repo/semantics/openAccess
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unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.