Listar QUIO_Articles por autoría "f538cdfc-9b18-4a50-b40e-4bfbe4996666"
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A minimalistic catalytically-active cell mimetic made of a supra-molecular hydrogel encapsulated into a polymersome
Martí-Centelles, Rosa; RUBIO-MAGNIETO, JENIFER; Escuder, Beatriu Royal Society of Chemistry (2020)A minimalistic multicomponent cell mimetic is described consisting of a fibrillar network formed by the self-assembly of a low molecular weight compound (cytoskeleton-like) that is entrapped into a polymersome (membrane-like), ... -
Cytotoxic, antiangiogenic and antitelomerase activity of glucosyl- and acyl- resveratrol prodrugs and resveratrol sulfate metabolites
Falomir, Eva; Lucas, Ricardo; Peñalver, Pablo; Martí-Centelles, Rosa; Dupont, Alexia; Zafra Gómez, Alberto; Carda, Miguel; Morales, Juan C. (2016-06)Resveratrol (RES) is a natural polyphenol with relevant and varied biological activity. However, its low bioavailability and rapid metabolism to its glucuronate and sulfate conjugates has opened a debate on the mechanisms ... -
Effects of Curcuminoid Pyrazoles on Cancer Cells and on the Expression of Telomerase Related Genes
Martí-Centelles, Rosa; Falomir, Eva; Carda, Miguel; Nieto, Carla I.; Cornago, M. Pilar; Claramunt, Rosa M. Wiley (2016-07)A group of 13 curcuminoid pyrazoles was investigated for their cytotoxicity on three tumoral cell lines (HT-29, MCF-7, and HeLa) and one non-tumoral human cell line (HEK-293). The values obtained were compared with those ... -
Inhibition of VEGF Expression in Cancer Cells and Endothelial Cell Differentiation by Synthetic Stilbene Derivatives
Martí-Centelles, Rosa; Cejudo Marín, Rocío; Falomir, Eva; Murga, Juan; Carda, Miguel; Marco, J. Alberto Elsevier (2013-06-01)We here report the synthesis of several stilbene derivatives. They show a measurable inhibitory effect on angiogenesis, some of them to a higher degree than resveratrol. Test methods included cell proliferation and tube ... -
Inhibitory effect of cytotoxic nitrogen-containing heterocyclic stilbene analogues on VEGF protein secretion and VEGF, hTERT and c-Myc gene expression
Martí-Centelles, Rosa; Murga, Juan; Falomir, Eva; Carda, Miguel; Marco, J. Alberto The Royal Society of Chemistry (2015)A group of 21 nitrogen-containing heterocyclic stilbene derivatives, prepared by means of Heck coupling reactions, has been investigated for their cytotoxicity as well as their ability to inhibit the production of the ... -
Inhibitory effect of cytotoxic stilbenes related to resveratrol on the expression of the VEGF, hTERT and c-Myc genes
Martí-Centelles, Rosa; Falomir, Eva; Murga, Juan; Carda, Miguel; Marco, J. Alberto Elsevier (2015)A group of thirty-nine stilbene derivatives, prepared by means of Heck coupling reactions, has been investigated for their cytotoxicity, as well as for their ability to inhibit the production of the vascular endothelial ... -
Morphology Diversity of L‐Phenylalanine‐Based Short Peptide Supramolecular Aggregates and Hydrogels
Martí-Centelles, Rosa; Escuder, Beatriu Wiley (2018-08)Supramolecular aggregates and hydrogels of diverse morphologies can be obtained by replacing the widely studied aromatic N‐capping of phenylalanine derivatives by long alkyl chains. Simple changes in chain length and number ... -
One drug for two targets: Biological evaluation of antiretroviral agents endowed with antiproliferative activity
Botta, Lorenzo; Maccari, Giorgio; Calandro, Pierpaolo; Tiberi, Marika; Brai, Annalaura; Zamperini, Claudio; Canducci, Filippo; Chiariello, Mario; Martí-Centelles, Rosa; Falomir, Eva; Carda, Miguel Elsevier (2017-06-01)AIDS-related cancer diseases are malignancies with low incidence on healthy people that affect mostly subjects already immunocompromised. The connection between HIV/AIDS and these cancers has not been established yet, but ... -
Two-Component Peptidic Molecular Gels for Topical Drug Delivery of Naproxen
Martí-Centelles, Rosa; Dolz Pérez, Irene; De la O, Jaciel; Ontoria Oviedo, Imelda; Sepulveda, Pilar; Nebot Carda, Vicent J.; Vicent, Maria J.; Escuder, Beatriu American Chemical Society (2021-01-05)Transdermal drug delivery (TDD) is an advantageous and effective approach for the localized delivery of drugs; however, overcoming the high impermeability of the outermost layer of skin, the stratum corneum, represents a ...