Listar QUIO_Articles por autoría "d1e586d2-7ed2-4841-9ae7-fd8a6168897e"

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    • closedAccess   Arylureas derived from colchicine: Enhancement of colchicine oncogene downregulation activity 

      Blasco, Víctor; Cuñat, Ana Carmen; Sanz-Cervera, Juan F.; Marco, J. Alberto; Falomir, Eva; Murga, Juan; Carda, Miguel Elsevier (2018-04-25)
      Our efforts to get therapeutically useful colchicine derivatives for the treatment of cancer have led us to synthetize and biologically evaluate twenty-seven N,N′-disubstituted ureas containing a colchicine moiety and an ...

    • closedAccess   Design, synthesis and antimalarial evaluation of novel thiazole derivatives 

      Bueno, José María; Carda, Miguel; Crespo, Benigno; Cuñat, Ana Carmen; De Cozar, Cristina; León, María Luisa; Marco, J. Alberto; Roda, Nuria; Sanz-Cervera, Juan F. Elsevier (2016)
      As part of our medicinal chemistry program’s ongoing search for compounds with antimalarial activity, we prepared a series of thiazole analogs and conducted a SAR study analyzing their in vitro activities against the ...

    • openAccess   Synthesis and biological evaluation of cyclic derivatives of combretastatin A-4 containing group 14 elements 

      Blasco, Víctor; Murga, Juan; Falomir, Eva; Carda, Miguel; Royo, Santiago; Cuñat, Ana Carmen; Sanz-Cervera, Juan F.; Marco, J. Alberto Royal Society of Chemistry (2018)
      Several tricyclic compounds inspired by the structure of combretastatin A-4 and bearing group 14 elements have been synthesized by homocoupling lithiated aryl fragments followed by ring-closing metathesis. These tricyclic ...