Listar QUIO_Articles por autoría "a2056c95-99a9-4974-901b-a2c6382e3926"
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Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules
Marco, J. Alberto; García Pla, Jorge; Carda, Miguel; Murga, Juan; Falomir, Eva; Trigili, Chiara; Notararigo, Sara; Díaz, J. Fernando; Barasoain, Isabel Elsevier (2011-05)The preparation of a series of pironetin analogues with simplified structure is described. Their cytotoxic activity and their interactions with tubulin have been investigated. It has been found that, while less active than ... -
Synthesis and Biological Evaluation As Microtubule-Active Agents of Several Tetrahydrofuran and Spiroacetal Derivatives
Carda, Miguel; Murga, Juan; Angulo-Pachón, César A.; García Pla, Jorge; Diaz-Oltra, Santiago; Marco, J. Alberto; Trigili, Chiara; Redondo Horcajo, Mariano; Díaz, J. Fernando; Barasoain, Isabel Bentham Science (2013)The stereoselective preparation of several molecules containing structural fragments of the tetrahydrofuran and spiroacetal type is described. Their degree of cytotoxicity and their interactions with tubulin have been ... -
Synthesis and Biological Evaluation of a-Tubulin-Binding Pironetin Analogues with Enhanced Lipophilicity
Carda, Miguel; Murga, Juan; Falomir, Eva; Diaz-Oltra, Santiago; García Pla, Jorge; Paños Pérez, Julián; Trigili, Chiara; Díaz, J. Fernando; Barasoain, Isabel; Marco, J. Alberto Wiley-VCH Verlag (2013)The preparation of four new lipophilic analogues of the natural pyrone pironetin is described. The nine-carbon side chain of the latter has been replaced in one analogue by a 4-phenylbutyl chain and in the other three ... -
Synthesis and biological evaluation of truncated α-tubulin-binding pironetin analogues lacking alkyl pendants in the side chain or the dihydropyrone ring
Paños Pérez, Julián; Diaz-Oltra, Santiago; Sanchez Peris, Maria; García Pla, Jorge; Murga, Juan; Falomir, Eva; Carda, Miguel; Redondo Horcajo, Mariano; Fernando Díaz, J.; Barasoain, Isabel; Alberto Marco, J. Royal Society of Chemistry (2013)The preparation of several new truncated analogues of the natural dihydropyrone pironetin is described. They differ from the natural product mainly in the suppression of some of the alkyl pendants in either the side chain ...