Listar QUIO_Articles por autoría "5f8aafba-9c48-49d9-a26a-b8a85333282d"

Mostrando ítems 1-5 de 5

    • openAccess   Advances in the Development of SARS-CoV-2 Mpro Inhibitors 

      Agost Beltrán, Laura; De la Hoz Rodríguez, Sergio; Bou Iserte, Lledó; Rodríguez, Santiago; Fernández de la Pradilla Ibáñez, Adrián; González, Florenci MDPI (2022-04-14)
      Since the outbreak of COVID-19, one of the strategies used to search for new drugs has been to find inhibitors of the main protease (Mpro) of the virus SARS-CoV-2. Initially, previously reported inhibitors of related ...

    • closedAccess   Design, Synthesis and Evaluation of Fluorescent Analogues of Abscisic Acid 

      González, Florenci; Bou Iserte, Lledó; Miguel-López, Borja; De la Hoz Rodríguez, Sergio; Kersten, Christian; Sánchez-Sarasúa, Sandra; Espinosa-Fernández, Verónica; Sánchez-Pérez, Ana María Wiley (2020-07-13)
      A fluorescent analogue of abscisic acid has been prepared by combining (S)‐abscisic acid (ABA) with nitrobenzoxadiazole (NBD) fluorophore using ethanol amine as a linker. Isomerization of the double bond at the side chain ...

    • openAccess   Investigation of the Compatibility between Warheads and Peptidomimetic Sequences of Protease Inhibitors—A Comprehensive Reactivity and Selectivity Study 

      Müller, Patrick; Meta, Mergim; Meidner, Jan Laurenz; Schwickert, Marvin; Meyr, Jessica; Schwickert, Dr. Kevin; Kersten, Christian; Zimmer, Collin; Hammerschmidt, Stefan Josef; Frey, Ariane; Lahu, Albin; De la Hoz Rodríguez, Sergio; Agost Beltrán, Laura; Rodríguez, Santiago; Diemer, Kira; Neumann, Wilhelm; González, Florenci; Engels, Bernd; Schirmeister, Tanja MDPI (2023-04-13)
      : Covalent peptidomimetic protease inhibitors have gained a lot of attention in drug development in recent years. They are designed to covalently bind the catalytically active amino acids through electrophilic groups ...

    • openAccess   Peptidyl nitroalkene inhibitors of main protease rationalized by computational and crystallographic investigations as antivirals against SARS-CoV-2 

      Medrano Martin, Francisco Javier; De la Hoz Rodríguez, Sergio; Martí, Sergio; Arafet Cruz, Kemel; Schirmeister, Tanja; Hammerschmidt, Stefan Josef; Müller-Ruttloff, Christin; González-Martínez, Águeda; Santillana Heras, Elena; Ziebuhr, John; Romero Garrido, Antonio; Zimmer, Collin; Weldert, Annabelle Carolin; Zimmermann, Robert; Lodola, Alessio; Świderek, Katarzyna; Moliner, Vicent; González, Florenci Springer Nature (2024-01-18)
      The coronavirus disease 2019 (COVID-19) pandemic continues to represent a global public health issue. The viral main protease (Mpro) represents one of the most attractive targets for the development of antiviral drugs. ...

    • openAccess   Transcription factors HB21/40/53 trigger inflorescence arrest through abscisic acid accumulation at the end of flowering 

      Sánchez-Gerschon, Verónica; Martínez-Fernández, Irene; Gonzalez Bermudez, Maria R; De la Hoz Rodríguez, Sergio; González, Florenci; Lozano-Juste, Jorge; Ferrándiz, Cristina; Balanzà, Vicente Oxford University Press (2024-04-26)
      Flowers, and hence, fruits and seeds, are produced by the activity of the inflorescence meristem after the floral transition. In plants with indeterminate inflorescences, the final number of flowers produced by the ...