Listar QUIO_Articles por autoría "50ebe758-4a00-4081-a730-b658c85c91a9"
Mostrando ítems 41-53 de 53
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Synthesis and Biological Evaluation of Potential Oncoimmunomodulator Agents
Gil-Edo, Raquel; ESPEJO, SARA; Falomir, Eva; Carda, Miguel MDPI (2023-01-30)Fourteen triazole-scaffold derivatives were synthetized and biologically evaluated as potential oncoimmunomodultator agents by targeting both PD-L1 and c-Myc. First, the antiproliferative activity of these molecules on the ... -
Synthesis and biological evaluation of simplified pironetin analogues with modifications in the side chain and the lactone ring
Roldán Gómez, Steven; Cardona, Adrià; Conesa Milián, Laura; Murga, Juan; Falomir, Eva; Carda, Miguel; Marco, J. Alberto Royal Society of Chemistry (2017)The preparation of several new analogues of the natural dihydropyrone pironetin is described. They differ from the natural product mainly in the nature of the side chain and the lactone ring. Their cytotoxic activity has ... -
Synthesis and Biological Evaluation of Small Molecules as Potential Anticancer Multitarget Agents
Pla López, Alberto; Castillo, Raquel; Cejudo Marín, Rocío; García Pedrero, Olaya; Bakir Laso, Mariam; Falomir, Eva; Miguel Carda MDPI (2022-06-24)Twenty-six triazole-based derivatives were designed for targeting both PD-L1 (programmed death receptor ligand 1) and VEGFR-2 (vascular endothelial growth factor receptor 2). These compounds were synthetized and biologically ... -
Synthesis and biological evaluation of truncated α-tubulin-binding pironetin analogues lacking alkyl pendants in the side chain or the dihydropyrone ring
Paños Pérez, Julián; Diaz-Oltra, Santiago; Sanchez Peris, Maria; García Pla, Jorge; Murga, Juan; Falomir, Eva; Carda, Miguel; Redondo Horcajo, Mariano; Fernando Díaz, J.; Barasoain, Isabel; Alberto Marco, J. Royal Society of Chemistry (2013)The preparation of several new truncated analogues of the natural dihydropyrone pironetin is described. They differ from the natural product mainly in the suppression of some of the alkyl pendants in either the side chain ... -
Synthesis and biological properties of the cytotoxic 14-membered macrolides aspergillide A and B
Diaz-Oltra, Santiago; Angulo-Pachón, César A.; Murga, Juan; Falomir, Eva; Carda, Miguel; Marco, J. Alberto Wiley (2010-11-09)Total, stereoselective syntheses of the naturally occurring, cytotoxic macrolides aspergillide A and B are described. Olefin metatheses and asymmetric allylations were key steps in the synthetic sequences. Cytotoxicity ... -
Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressions
Sanchez Peris, Maria; Falomir, Eva; Murga, Juan; Carda, Miguel; Marco, J. Alberto Elsevier (2016)A group of 47 biphenyl functionalized compounds, prepared by means of Suzuki couplings, has been investigated for their cytotoxicity on two tumoral cell lines (HT-29 and MCF-7) and one non tumoral cell line (HEK-293). ... -
Synthesis of Combretastatin A-4 and 3 0 -Aminocombretastatin A-4 derivatives with Aminoacid Containing Pendants and Study of their Interaction with Tubulin and as Downregulators of the VEGF, hTERT and c-Myc Gene Expression
Agut, Raúl; Falomir, Eva; Murga, Juan; Martín Beltrán, Celia; Gil Edo, Raquel; Pla, Alberto; Carda, Miguel; Marco, J. Alberto MDPI (2020)Natural product combretastatin A-4 (CA-4) and its nitrogenated analogue 3 0 -aminocombretastatin A-4 (AmCA-4) have shown promising antitumor activities. In this study, a range of CA-4 and AmCA-4 derivatives containing ... -
Synthesis of combretastatin A-4 O-alkyl derivatives and evaluation of their cytotoxic, antiangiogenic and antitelomerase activity
Torijano Gutiérrez, Sandra Adela; Diaz-Oltra, Santiago; Falomir, Eva; Murga, Juan; Carda, Miguel; Marco, J. Alberto Elsevier (2013-12)We here report the synthesis and biological evaluation of several combretastatin A-4 derivatives alkylated at the phenol hydroxyl group. Some of these derivatives contain an (E)-arylalkene fragment reminiscent of that ... -
Synthesis of honokiol analogues and evaluation of their modulating action on VEGF protein secretion and telomerase-related gene expressions
Sanchez Peris, Maria; Murga, Juan; Falomir, Eva; Carda, Miguel; Marco, J. Alberto Wiley (2017-04)A group of 36 biphenyl derivatives structurally related to honokiol were synthesized by means of Suzuki coupling reactions. Their cytotoxicities were evaluated and compared to that of honokiol. Some of the compounds were ... -
Synthesis, Binding Properties, and Differences in Cell Uptake of G-Quadruplex Ligands Based on Carbohydrate Naphthalene Diimide Conjugates
Arevalo-Ruiz, Matilde; Doria, Filippo; Belmonte Reche, Efres; De Rache, Aurore; Campos-Salinas, Jenny; Lucas, Ricardo; Falomir, Eva; Carda, Miguel; Pérez-Victoria, José María; Mergny, Jean-Louis Wiley (2017-02-10)The G-quadruplexes (G4s) are currently being explored as therapeutic targets in cancer and other pathologies. Six carbohydrate naphthalene diimide conjugates (carb-NDIs) have been synthesized as G4 ligands to investigate ... -
Tetrazole derivatives as potent immunomodulatory agents in tumor microenvironment
Pla López, Alberto; Carda, Miguel; Falomir, Eva Elsevier (2023-11-01)Twenty-seven compounds bearing a tetrazole ring as a central unit have been designed, synthetized and biologically evaluated. Studies have been performed in order to compare the effect of tetrazole derivatives bearing amine ... -
The Mechanism of the Interactions of Pironetin Analog/Combretastatin A-4 Hybrids with Tubulin
Torijano Gutiérrez, Sandra Adela; Vilanova Gallén, Concepción; Diaz-Oltra, Santiago; Murga, Juan; Falomir, Eva; Carda, Miguel; Redondo Horcajo, Mariano; Fernando Díaz, J.; Barasoain, Isabel; Marco, J. Alberto Wiley (2015-06-17)We here report an investigation of the interactions with tubulin of two types of molecules of a hybrid structural type consisting in a combretastatin A-4 moiety and a simplified pironetin fragment. The cytotoxicities of ... -
Unveiling the Potential of BenzylethyleneAryl–Urea Scaffolds for the Design of New Onco Immunomodulating Agents
Gil-Edo, Raquel; Royo, Santiago; Carda, Miguel; Falomir, Eva MDPI (2023)This work focuses on the development of thirteen benzylethylenearyl ureas and one carbamate. After the synthesis and purification of the compounds, we studied their antiproliferative action on cell lines, such as HEK-293, ...