Listar QUIO_Articles por autoría "50ebe758-4a00-4081-a730-b658c85c91a9"
Mostrando ítems 21-40 de 53
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Inhibitory effect of cytotoxic nitrogen-containing heterocyclic stilbene analogues on VEGF protein secretion and VEGF, hTERT and c-Myc gene expression
Martí-Centelles, Rosa; Murga, Juan; Falomir, Eva; Carda, Miguel; Marco, J. Alberto The Royal Society of Chemistry (2015)A group of 21 nitrogen-containing heterocyclic stilbene derivatives, prepared by means of Heck coupling reactions, has been investigated for their cytotoxicity as well as their ability to inhibit the production of the ... -
Inhibitory effect of cytotoxic stilbenes related to resveratrol on the expression of the VEGF, hTERT and c-Myc genes
Martí-Centelles, Rosa; Falomir, Eva; Murga, Juan; Carda, Miguel; Marco, J. Alberto Elsevier (2015)A group of thirty-nine stilbene derivatives, prepared by means of Heck coupling reactions, has been investigated for their cytotoxicity, as well as for their ability to inhibit the production of the vascular endothelial ... -
Inhibitory effect of pironetin analogue/colchicine hybrids on the expression of the VEGF, hTERT and c-Myc genes
Vilanova Gallén, Concepción; Diaz-Oltra, Santiago; Murga, Juan; Falomir, Eva; Carda, Miguel; Marco, J. Alberto Elsevier (2015-08)A small group of hybrid molecules composed of a colchicine moiety and a pironetin analogue fragment have been investigated for their ability to inhibit the expression of the VEGF, hTERT and c-Myc genes. The VEGF gene is ... -
Interactions of long-chain homologues of colchicine with tubulin
Marzo Mas, Ana; Barbier, Pascale; Breuzard, Gilles; Allegro, Diane; Falomir, Eva; Murga, Juan; Carda, Miguel; Peyrot, Vincent; Marco, J. Alberto Elsevier (2017-01)Several colchicine analogues in which the N-acetyl residue has been replaced by aliphatic, straight-chain acyl moieties, have been synthesized. These compounds show high cytotoxic activity at the nanomolar level against ... -
N-alpha-Aminoacyl Colchicines as Promising Anticancer Agents
Marzo Mas, Ana; Conesa Milián, Laura; Noppen, Sam; Liekens, Sandra; Falomir, Eva; Murga, Juan; Carda, Miguel; Marco, J. Alberto Bentham Science Publishers (2020-12-29)Background: In the last years, many efforts have been made to find colchicine derivatives with reduced toxicity. Additionally, the deregulation of amino acid uptake by cancer cells provides an opportunity to improve ... -
Non-Polymeric Nanogels as Versatile Nanocarriers: Intracellular Transport of the Photosensitizers Rose Bengal and Hypericin for Photodynamic Therapy
Torres-Martínez, Ana; Bedrina, Begoña; Falomir, Eva; Marín, María J.; Angulo-Pachón, César A.; Galindo, Francisco; Miravet, Juan American Chemical Society (2021-04-19)The use of nanocarriers for intracellular transport of actives has been extensively studied in recent years and represents a central area of nanomedicine. The main novelty of this paper lies on the use of nanogels formed ... -
Novel multitarget inhibitors with antiangiogenic and immunomodulator properties
Conesa Milián, Laura; Falomir, Eva; Murga, Juan; Carda, Miguel; Marco, J. Alberto Elsevier (2019-03-08)By means of docking studies, seventeen compounds T.1-T17 have been designed and evaluated as multitarget inhibitors of VEGFR-2 and PD-L1 proteins in order to overcome resistance phenomena offered by cancer. All these ... -
One drug for two targets: Biological evaluation of antiretroviral agents endowed with antiproliferative activity
Botta, Lorenzo; Maccari, Giorgio; Calandro, Pierpaolo; Tiberi, Marika; Brai, Annalaura; Zamperini, Claudio; Canducci, Filippo; Chiariello, Mario; Martí-Centelles, Rosa; Falomir, Eva; Carda, Miguel Elsevier (2017-06-01)AIDS-related cancer diseases are malignancies with low incidence on healthy people that affect mostly subjects already immunocompromised. The connection between HIV/AIDS and these cancers has not been established yet, but ... -
Pulsed laser fragmentation synthesis of carbon quantum dots (CQDs) as fluorescent probes in non-enzymatic glucose detection
Cortes, Francis Rey; Falomir, Eva; Lancis, Jesús; Mínguez-Vega, Gladys Elsevier (2024-08-30)Pulsed laser fragmentation in liquid (PLFL) is one of the synthesis routes for producing high-purity carbon quantum dots (CQDs) with less toxic by-products in a straightforward system. The limited literature regarding the ... -
Self‐Assembled Nanofibrilar Networks: Boosting Hydrogelation Efficiency by Replacement of a Pyridine Moiety by a Quinoline One
Angulo-Pachón, César A.; Diaz-Oltra, Santiago; Ojeda, Juan José; Falomir, Eva; Galindo, Francisco; Miravet, Juan Wiley (2015-08)A new molecular hydrogelator consisting of a L‐Valine derivative with appended quinoline units behaves as a supramolecular superhydrogelator forming gels at such low concentrations as 0.8 mM (0.05% w/w). On the other hand, ... -
Short, Stereoselective Synthesis of the Naturally Occurring Pyrrolidine Radicamine B and a Formal Synthesis of Nectrisine
Ribés Vidal, Celia; Falomir, Eva; Carda, Miguel; Marco, J. Alberto American Chemical Society (2008)A short, stereoselective synthesis of the naturally occurring pyrrolidine radicamine B is reported. Garner′s (R)-aldehyde, prepared from d-serine, was the chiral starting material. The pyrrolidine ring was stereoselectively ... -
Small Molecules as Toll-like Receptor 4 Modulators Drug and In-House Computational Repurposing
Pérez-Regidor, Lucía; Guzmán-Caldentey, Joan; Oberhauser, Nils; Punzón, Carmen; Balogh, Balázs; Pedro, Jose R.; Falomir, Eva; Nurisso, Alessandra; Mátyus, Péter; Menéndez, J. Carlos; de Andrés, Belén; Fresno Escudero, Manuel; Martin-Santamaria, Sonsoles MDPI (2022-09)The innate immunity toll-like receptor 4 (TLR4) system is a receptor of paramount importance as a therapeutic target. Virtual screening following a “computer-aided drug repurposing” approach was applied to the discovery ... -
Solanum lycopersicum heme-binding protein 2 as a potent antimicrobial weapon against plant pathogens
Farvardin, Atefeh; Llorens, Eugenio; Liu, Luisa; Sánchez-Giménez, Lorena; Wong, Aloysius; González Biosca, Elena; Pedra Tellols, José Miguel; Falomir, Eva; Camañes, Gemma; Scalschi, Loredana; Vicedo, Begonya Nature Research (2023)The rise in antibiotic-resistant bacteria caused by the excessive use of antibiotics has led to the urgent exploration of alternative antimicrobial solutions. Among these alternatives, antimicrobial proteins, and peptides ... -
Stereoselective syntheses of the glycosidase inhibitors hyacinthacine A2, hyacinthacine A3 and 5-epi-hyacinthacine A3
Ribés Vidal, Celia; Falomir, Eva; Carda, Miguel; Marco, J. Alberto Elsevier (2009)Stereoselective syntheses of the naturally occurring glycosidase inhibitors hyacinthacines A2 and A3 are reported. In the case of hyacinthacine A2, the pyrrolizidine system was created from an acyclic precursor via a double ... -
Stereoselective synthesis of the naturally occurring 2-pyranone dodoneine
Álvarez Bercedo, Paula; Falomir, Eva; Murga, Juan; Carda, Miguel; Marco, J. Alberto Wiley-VCH (2008-08)The first total synthesis of the naturally occurring dihydropyranone dodoneine is reported. Asymmetric allylations were used for the stereoselective generation of the two stereogenic centers. The pyranone ring was created ... -
Styryl carbamate backbones for the discovery of TME-disrupting agents
Bou Puerto, Amelia; Carda, Miguel; Falomir, Eva Elsevier (2024)Twenty-one styryl carbamates have been designed, synthetized and characterized by their physical properties. Afterwards, their potential activity as tumor microenvironment disruptors has been evaluated. First, antiproliferative ... -
Synthesis and biological evaluation as antiangiogenic agents of ureas derived from 3′-aminocombretastatin A-4
Conesa Milián, Laura; Falomir, Eva; Murga, Juan; Carda, Miguel; Marco, J. Alberto Elsevier (2019-01-15)Twenty-six compounds derived from 3′-aminocombretastatin A-4 (AmCA-4) containing a urea fragment mimicking the structure of Sorafenib, have been synthesized and evaluated as antiangiogenic compounds. Antiproliferative ... -
Synthesis and Biological Evaluation of a-Tubulin-Binding Pironetin Analogues with Enhanced Lipophilicity
Carda, Miguel; Murga, Juan; Falomir, Eva; Diaz-Oltra, Santiago; García Pla, Jorge; Paños Pérez, Julián; Trigili, Chiara; Díaz, J. Fernando; Barasoain, Isabel; Marco, J. Alberto Wiley-VCH Verlag (2013)The preparation of four new lipophilic analogues of the natural pyrone pironetin is described. The nine-carbon side chain of the latter has been replaced in one analogue by a 4-phenylbutyl chain and in the other three ... -
Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents
Conesa Milián, Laura; Falomir, Eva; Murga, Juan; Carda, Miguel; Meyen, Eef; Liekens, Sandra; Marco, J. Alberto Elsevier (2018-03-10)A series of t wenty-six carbamates derived from aminocombretastatin A- 4 (AmCA-4 ) were syn thesized and evaluated for their capacity to affect cell proliferation, tubulin polymerization, mitotic cell arrest, microtubule ... -
Synthesis and biological evaluation of cyclic derivatives of combretastatin A-4 containing group 14 elements
Blasco, Víctor; Murga, Juan; Falomir, Eva; Carda, Miguel; Royo, Santiago; Cuñat, Ana Carmen; Sanz-Cervera, Juan F.; Marco, J. Alberto Royal Society of Chemistry (2018)Several tricyclic compounds inspired by the structure of combretastatin A-4 and bearing group 14 elements have been synthesized by homocoupling lithiated aryl fragments followed by ring-closing metathesis. These tricyclic ...