Listar QUIO_Articles por autoría "4cb00856-43db-4556-b3c3-10863763387a"
Mostrando ítems 1-2 de 2
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5-Hydroxy-5-methylhydantoin DNA lesion, a molecular trap for DNA glycosylases
Le Bihan, Yann-Vaï; Izquierdo Arcusa, María Ángeles; Coste, Franck; Aller, Pierre; Culard, Françoise; Gehrke, Tim H.; Essalhi, Kadija; Carell, Thomas; Castaing, Bertrand Oxford University Press (2011-04-12)DNA base-damage recognition in the base excision repair (BER) is a process operating on a wide variety of alkylated, oxidized and degraded bases. DNA glycosylases are the key enzymes which initiate the BER pathway by ... -
Bacterial base excision repair enzyme Fpg recognizes bulky N7-substituted-FapydG lesion via unproductive binding mode
Coste, Franck; Ober, Matthias; Le Bihan, Yann-Vaï; Izquierdo Arcusa, María Ángeles (2012-07-18)Fpg is a bacterial base excision repair enzyme that removes oxidized purines from DNA. This work shows that Fpg and its eukaryote homolog Ogg1 recognize with high affinity FapydG and bulky N7-benzyl-FapydG (Bz-FapydG). The ...