Listar QUIO_Articles por autoría "44443de8-d317-4f6f-8d85-e25c0e052e7d"
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Furanchalcone–biphenyl hybrids: synthesis, in silico studies, antitrypanosomal and cytotoxic activities
García, Elisa; Ochoa, Rodrigo; Vasquez, Isabel; Conesa Milián, Laura; Carda, Miguel; Yepes, Andrés; Vélez, Iván D.; Robledo, Sara M.; Cardona Galeano, Wilson Isidro Springer Verlag (2019)The synthesis, antitrypanosomal, and cytotoxic activities of 17 furanchalcone derivatives are described herein. The structure of the synthesized products was elucidated by a combination of spectrometric analyses. The ... -
Synthesis and antiprotozoal activity of furanchalcone–quinoline, furanchalcone–chromone and furanchalcone–imidazole hybrids
García, Elisa; Coa, Juan Carlos; Otero, Elver; Carda, Miguel; Vélez, Iván D.; Robledo, Sara M.; Cardona Galeano, Wilson Isidro Springer Verlag (2018)We report herein the synthesis and biological activities (cytotoxicity, leishmanicidal, and trypanocidal) of several furanchalcone–quinoline, furanchalcone–chromone, and furanchalcone–imidazole hybrids. The synthesized ... -
Synthesis and leishmanicidal activity of cinnamic acid esters: structure–activity relationship
Otero, Elver; Robledo, Sara M.; Diaz-Oltra, Santiago; Carda, Miguel; Muñoz, Diana; Paños Pérez, Julián; Vélez, Iván D.; Cardona Galeano, Wilson Isidro Springer (2014)Several cinnamic acid esters were obtained via Fischer esterification of cinnamic acids derivatives with aliphatic alcohols. Structures of the products were elucidated by spectroscopic analysis. The synthesized compounds ... -
Synthesis, antiprotozoal activity and cytotoxicity in U-937 macrophages of triclosan–hydrazone hybrids
Vergara, Sebastián; Carda, Miguel; Agut, Raúl; Yepes, Lina M.; Vélez, Iván D.; Robledo, Sara M. Springer Verlag (2017)The synthesis and biological activities (cytotoxicity, leishmanicidal, and trypanocidal) of 11 triclosan–hydrazone hybrids are described herein. The structure of the products was elucidated by spectral data (NMR, IR) and ... -
Synthesis, Leishmanicidal and Cytotoxic Activity of Triclosan-Chalcone, Triclosan-Chromone and Triclosan-Coumarin Hybrids
Otero, Elver; Vergara, Sebastián; Robledo, Sara M.; Cardona Galeano, Wilson Isidro; Carda, Miguel; Vélez, Iván D.; Rojas, Carlos; Otálvaro, Felipe (MDPI) Digital Publishing Institute (2014)Twelve hybrids derived from triclosan were obtained via Williamson etherification of O-triclosan alkyl bromide plus chalcone and O-coumarin or O-chromone alkyl bromide plus triclosan, respectively. Structures of the products ... -
Synthesis, leishmanicidal, trypanocidal and cytotoxic activities of quinoline-chalcone and quinoline-chromone hybrids
Coa, Juan Carlos; García, Elisa; Carda, Miguel; Agut, Raúl; Vélez, Iván D.; Muñoz, July A.; Yepes, Lina M.; Robledo, Sara M. Springer Verlag (2017)We report herein the synthesis and biological activities (cytotoxicity, leishmanicidal and trypanocidal) of six quinoline-chalcone and five quinoline-chromone hybrids. The synthesized compounds were evaluated against ... -
Synthesis, leishmanicidal, trypanocidal and cytotoxic activity of quinoline-hydrazone hybrids
Coa, Juan Carlos; Castrillón, Wilson; Cardona Galeano, Wilson Isidro; Carda, Miguel; Ospina, Victoria; Muñoz, July Andrea; Vélez, Iván D.; Robledo, Sara M. Elsevier (2015)Cutaneous leishmaniasis and Chagas disease are vector-borne parasitic disease causing serious risks to million people living in poverty-stricken areas. Both diseases are a major health problem in Latin America, and currently ... -
Triclosan-caffeic acid hybrids: Synthesis, leishmanicidal, trypanocidal and cytotoxic activities
Otero, Elver; García, Elisa; Palacios, Génesis; Yepes, Lina M.; Carda, Miguel; Agut, Raúl; Vélez, Iván D.; Cardona Galeano, Wilson Isidro; Robledo, Sara M. Elsevier (2017-09-29)The synthesis, cytotoxicity, anti-leishmanial and anti-trypanosomal activities of twelve triclosan-caffeic acid hybrids are described herein. The structure of the synthesized products was elucidated by a com- bination ...