Listar QFA_Articles por fuente "Physical Chemistry Chemical Physics, 2015"
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The influence of active site conformations on the hydride transfer step of the thymidylate synthase reaction mechanism
Royal Society of Chemistry (2015)The hydride transfer from C6 of tetrahydrofolate to the reaction's exocyclic methylene–dUMP intermediate is the rate limiting step in thymidylate synthase (TSase) catalysis. This step has been studied by means of QM/MM ...