Browsing QFA_Articles by Author "b47bbf9f-57ff-49b9-b76f-5410726a7e97"
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Experimental and Computational Studies Delineate the Role of Asparagine 177 in Hydride Transfer for E. coli Thymidylate Synthase
Gurevic, Ilya; Islam, Zahidul; Świderek, Katarzyna; Trepka, Kai; Ghosh, Ananda K; Moliner, Vicent; Kohen, Amnon American Chemical Society (2018)Thymidylate synthase (TSase), an enzyme responsible for the de novo biosynthesis of 2′-deoxythymidine 5′-monophosphate (thymidylate, dTMP) necessary for DNA synthesis, has been a drug target for decades. TSase is a highly ... -
Parallel reaction pathways and noncovalent intermediates in thymidylate synthase revealed by experimental and computational tools
Kholodar, Svetlana; Ghosh, Ananda K; Świderek, Katarzyna; Moliner, Vicent; Kohen, Amnon National Academy of Sciences (2018)Thymidylate synthase was one of the most studied enzymes due to its critical role in molecular pathogenesis of cancer. Nevertheless, many atomistic details of its chemical mechanism remain unknown or debated, thereby ...