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Elucidating the Catalytic Reaction Mechanism of Orotate Phosphoribosyltransferase by Means of X‑ray Crystallography and Computational Simulations
Roca, Maite; Navas Yuste, Sergio; Zinovjev, Kirill; López-Estepa, Miguel; Gómez, Sara; Fernández, Francisco J.; Vega, M. Cristina; Tuñón, Iñaki American Chemical Society (2020-01-02)Orotate phosphoribosyltransferase (OPRTase) catalyzes the reaction between the ribose donor α-d-5-phosphoribosyl-1-pyrophosphate (PRPP) and orotate (OA) in the presence of Mg2+ ion to obtain pyrophosphate and pyrimidine ...