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Ara mostrant els elements 1-2 d 2
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Glycoside hydrolase stabilization of transition state charge: new directions for inhibitor design
Ren, Weiwu; Farren-Dai, Marco; Sannikova, Natalia; Świderek, Katarzyna; Wang, Yang; Akintola, Oluwafemi; Britton, Robert; Moliner, Vicent; Bennet, Andrew J. Royal Society of Chemistry (2020)Carbasugars are structural mimics of naturally occurring carbohydrates that can interact with and inhibit enzymes involved in carbohydrate processing. In particular, carbasugars have attracted attention as inhibitors of ... -
Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level
Ren, Weiwu; Pengelly, Robert; Farren-Dai, Marco; Shamsi Kazem Abadi, Saeideh; Oehler, Verena; Akintola, Oluwafemi; Draper, Jason; Meanwell, Michael; Chakladar, Saswati; Świderek, Katarzyna; Moliner, Vicent; Britton, Robert; Gloster, Tracey M.; Bennet, Andrew J. Nature Research (2018)Mechanism-based glycoside hydrolase inhibitors are carbohydrate analogs that mimic the natural substrate’s structure. Their covalent bond formation with the glycoside hydrolase makes these compounds excellent tools for ...