• closedAccess   Induction of brain cytochrome P450 2E1 boosts the locomotor-stimulating effects of ethanol in mice 

      Ledesma Llorente, Juan Carlos; MIQUEL, MARTA; Pascual, María; Guerri, Consuelo; González Aragón, Carlos Manuel Elsevier (2014)
      In the central nervous system ethanol (EtOH) is metabolized into acetaldehyde by different enzymes. Brain catalase accounts for 60% of the total production of EtOH-derived acetaldehyde, whereas cerebral cytochrome P450 2E1 ...
    • closedAccess   Role of CA2+/calmodulin on ethanol neurobehavioral effects 

      González Aragón, Carlos Manuel; Ledesma Llorente, Juan Carlos; Baliño, Pablo Springer (2014-05)
      Rationale. The cAMP-dependent protein kinase A (PKA) signaling transduction pathway has been shown to play an important role in the modulation of several ethanol-induced behaviors. Different studies have demonstrated ...