ListarPSB_Articles por tema "Motivation"
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Adenosine A2A receptor antagonism and genetic deletion attenuate the effects of dopamine D2 antagonism on effort-based decision making in mice
Elsevier (2012)Brain dopamine (DA) and adenosine interact in the regulation of behavioral activation and effort-related processes. In the present studies, a T-maze task was developed in mice for the assessment of effort-related decision ... -
Assessment of a glycine uptake inhibitor in animal models of effort-related choice behavior: implications for motivational dysfunctions
Springer Verlag (2017)Rationale Motivated behavior can be characterized by a substantial exertion of effort, and organisms often make effortrelated decisions based upon analyses of work-related response costs and reinforcement preference. ... -
Assessment of a glycine uptake inhibitor in animal models of effort-related choice behavior: implications for motivational dysfunctions
Springer Verlag (2017)Rationale Motivated behavior can be characterized by a substantial exertion of effort, and organisms often make effortrelated decisions based upon analyses of work-related response costs and reinforcement preference. ... -
Behavioral and dopamine transporter binding properties of the modafinil analog (S, S)-CE-158: reversal of the motivational effects of tetrabenazine and enhancement of progressive ratio responding
Springer (2020)Rationale Atypical dopamine (DA) transport blockers such as modafinil and its analogs may be useful for treating motivational symptoms of depression and other disorders. Previous research has shown that the DA depleting ... -
Blockade of uptake for dopamine, but not norepinephrine or 5-HT, increases selection of high effort instrumental activity: Implications for treatment of effort-related motivational symptoms in psychopathology
Elsevier (2016)Deficits in behavioral activation, exertion of effort, and other psychomotor/motivational symptoms are frequently seen in people with depression and other disorders. Depressed people show a decision bias towards selection ... -
Differential effects of selective adenosine antagonists on the effort-related impairments induced by dopamine D1 and D2 antagonism
Elsevier (2010)Mesolimbic dopamine (DA) is a critical component of the brain circuitry regulating behavioral activation and effort-related processes. Rats with impaired DA transmission reallocate their instrumental behavior away from ... -
Dopamine depletion shifts behavior from activity based reinforcers tomore sedentary ones and adenosine receptor antagonism reversesthat shift: Relation to ventral striatum DARPP32 phosphorylationpatterns
Elsevier (2018)The mesolimbic dopamine (DA) system plays a critical role in behavioral activation and effort-baseddecision-making. DA depletion produces anergia (shifts to low effort options) in animals tested oneffort-based decision-making ... -
Dopamine, behavioral economics, and effort
Frontiers Research Foundation (2009)There are numerous problems with the hypothesis that brain dopamine (DA) systems, particularly in the nucleus accumbens, directly mediate the rewarding or primary motivational characteristics of natural stimuli such as ... -
Dopamine, Effort-Based Choice, and Behavioral Economics: Basic and Translational Research
Frontiers Media (2018-03)Operant behavior is not only regulated by factors related to the quality or quantity of reinforcement, but also by the work requirements inherent in performing instrumental actions. Moreover, organisms often make ... -
Dopamine/adenosine interactions involved in effort-related aspects of food motivation
Elsevier (2009)Nucleus accumbens dopamine (DA) is involved in effort-related aspects of food motivation. Accumbens DA depletions reduce the tendency of rats to work for food, and alter effort-related choice, but leave other aspects of ... -
Dopamine/adenosine interactions related to locomotion and tremor in animal models: Possible relevance to parkinsonism
Elsevier (2008)Adenosine A<sub>2A</sub> antagonists can exert antiparkinsonian effects in animal models. Recent experiments studied the ability of MSX-3 (an adenosine A<sub>2A</sub> antagonist) to reverse the locomotor suppression and ... -
Effects of lisdexamfetamine and s-citalopram, alone and in combination, on effort-related choice behavior in the rat
Springer Verlag (2016)Rationale Effort-related motivational symptoms, such as anergia, psychomotor retardation, and fatigue, are an important aspect of depression and other disorders. Motivational symptoms are resistant to some treatments, ... -
Effort-related decision making in humanized COMT mice: Effects ofVal158Met polymorphisms and possible implications for negative symptomsin humans
Elsevier (2020)Catechol-o-methyltransferase (COMT) is an enzyme that metabolizes catecholamines, and is crucial for clearanceof dopamine (DA) in prefrontal cortex. Val158Met polymorphism, which causes a valine (Val) to methionine(Met) ... -
Effort-related motivational effects of the pro-inflammatory cytokine interleukin-6: pharmacological and neurochemical characterization
Springer Verlag (2016)Rationale Motivational dysfunctions such as anergia, fatigue, and reduced effort expenditure are common in patients with depression and other disorders. Pro-inflammatory cytokines are implicated in depression, and ... -
Evaluation of the effort-related motivational effects of the novel dopamine uptake inhibitor PRX-14040
Elsevier (2016)Psychiatric disorders are often marked by effort-related motivational symptoms such as anergia, fatigue, psychomotor retardation, and alterations in effort-based decision making. Animal studies of effort-related choice ... -
Intra-accumbens injections of the adenosine A(2A) agonist CGS 21680 affect effort-related choice behavior in rats
Springer Verlag (2008)Rationale: Nucleus accumbens dopamine (DA) participates in the modulation of instrumental behavior, including aspects of behavioral activation and effort-related choice behavior. Rats with impaired accumbens DA transmission ... -
Lisdexamfetamine suppresses instrumental and consummatory behaviorssupported by foods with varying degrees of palatability: Exploration of abinge-like eating model
Elsevier (2020)Diets high in sugar or fat are associated with multiple health conditions, including binge eating disorder (BED). BED affects approximately 2% of the US adult population, and occurs more frequently in females. It is important ... -
Neurobiological basis of motivational deficits in psychopathology
Elsevier (2015)In recent years, there has been increasing emphasis on the importance of motivational symptoms in depression, schizophrenia and other disorders. The present review discusses the conceptual background related to the construct ... -
Nucleus Accumbens Adenosine A2A Receptors Regulate Exertion of Effort by Acting on the Ventral Striatopallidal Pathway
Society for Neuroscience (2008)Goal-directed actions are sensitive to work-related response costs, and dopamine in nucleus accumbens is thought to modulate the exertion of effort in motivated behavior. Dopamine-rich striatal areas such as nucleus ... -
Nucleus accumbens neurotransmission and effort-related choice behavior in food motivation: Effects of drugs acting on dopamine, adenosine, and muscarinic acetylcholine receptors
Elsevier (2013)Mesolimbic dopamine (DA) is a critical component of the brain circuitry regulating behavioral activation and effort-related processes. Although nucleus accumbens (NAc) DA depletions or antagonism leave aspects of appetite ...